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日期	題名	關聯
2024-10-29	DBPR116, a prodrug of BPRMU191, in combination with naltrexone as a safer opioid analgesic than morphine via peripheral administration	Journal of Medicinal Chemistry. 2024 Oct 29;Article in Press.
2024-07-17	Discovery of a mu-opioid receptor modulator that in combination with morphinan antagonists induces analgesia	Cell Chemical Biology. 2024 Jul 17;Article in Press.
2023-10-05	A dual nociceptin and mu opioid receptor agonist exhibited robust antinociceptive effect with decreased side effects	European Journal of Medicinal Chemistry. 2023 Oct 05;258:Article number 115608.
2022-12-05	Benzo[b]thiophene-2-carboxamides as novel opioid receptor agonists with potent analgesic effect and reduced constipation	European Journal of Medicinal Chemistry. 2022 Dec 5;243:Article number 114728.
2022-11	Selective and antagonist-dependent µ-opioid receptor activation by the combination of 2-{[2-(6-chloro-3,4-dihydro-1(2H)-quinolinyl)-2-oxoethyl]sulfanyl}-5-phenyl-4,6-(1H,5H)-pyrimidinedione and naloxone/naltrexone	Bioorganic Chemistry. 2022 Nov;128:Article number 105905.
2020-10-08	Comparative study between deep learning and QSAR classifications for TNBC inhibitors and novel GPCR agonist discovery	Scientific Reports. 2020 Oct 8;10:Article number 16771.
2020-10	Increased activation of HDAC1/2/6 and Sp1 underlies therapeutic resistance and tumor growth in glioblastoma	Neuro-Oncology. 2020 Oct;22(10):1439-1451.
2020-06	Morphine produces potent antinociception, sedation, and hypothermia in humanized mice expressing human mu opioid receptor splice variants	Pain. 2020 Jun;161(6):1177-1190.
2020-04-15	Betulinic acid-mediated tuning of PERK/CHOP signaling by Sp1 inhibition as a novel therapeutic strategy for glioblastoma	Cancers. 2020 Apr 15;12(4):Article number 981.
2020-04	BPR1M97, a dual mu opioid receptor/nociceptin-orphanin FQ peptide receptor agonist, produces potent antinociceptive effects with safer properties than morphine	Neuropharmacology. 2020 Apr;166:Article number 107678.
2020-04	Pharmacological studies of morphine in a novel humanized mu opioid receptor mouse model	FASEB Journal. 2020 Apr;34(S1):Abstract number 02835.
2019-04-01	The in vivo antinociceptive and mu-opioid receptor activating effects of the combination of N-phenyl-2′,4′-dimethyl-4,5′-bi-1,3-thiazol-2-amines and naloxone	European Journal of Medicinal Chemistry. 2019 Apr 1;167:312-323.
2019-02-20	Convallatoxin enhance the ligand-induced mu-opioid receptor endocytosis and attenuate morphine antinociceptive tolerance in mice	Scientific Reports. 2019 Feb 20;9:Article number 2405.
2018-08-04	Upregulation of Znf179 acetylation by SAHA protects cells against oxidative stress	Redox Biology. 2018 Aug 4;19:74-80.
2017-05	1-(2,4-Dibromophenyl)-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one: A novel opioid receptor agonist with less accompanying gastrointestinal dysfunction than morphine	Anesthesiology. 2017 May;126(5):952-966.
2017-04	Specificity protein 1-zinc finger protein 179 pathway is involved in the attenuation of oxidative stress following brain injury	Redox Biology. 2017 Apr;11:135-143.
2017-03	Mapping the naloxone binding sites on the mu-opioid receptor using cell-based photocrosslinkers	Biochimica Et Biophysica Acta(BBA)-Proteins and Proteomics. 2017 Mar;1865(3):336-343.
2017-01	Discovery, structure-activity relationship studies, and anti-nociceptive effects of N-(1,2,3,4-tetrahydro-1-isoquinolinylmethyl)benzamides as novel opioid receptor agonists	European Journal of Medicinal Chemistry. 2017 Jan;126:202-217.
2016-06	The sigma-1 receptor-zinc finger protein 179 pathway protects against hydrogen peroxide-induced cell injury	Neuropharmacology. 2016 Jun;105:1-9.
2015-10	Identification of substituted naphthotriazolediones as novel tryptophan 2,3-dioxygenase (TDO) inhibitors through structure-based virtual screening	Journal of Medicinal Chemistry. 2015 Oct;58 (19):7807-7819.
2014-12-01	Morphine drives internal ribosome entry site-mediated hnRNP K translation in neurons through opioid receptor-dependent signaling	Nucleic Acids Research. 2014 Dec 1;42(21):13012-13025.
2014-09	Discovery, structure-activity relationship studies, and anti-nociceptive effects of 1-phenyl-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one as novel opioid receptor agonists	Bioorganic and Medicinal Chemistry. 2014 Sep;22(17): 4694-4703.
2012-06-29	58-kDa microspherule protein (MSP58) is novel Brahma-related gene 1 (BRG1)-associated protein that modulates p53/p21 senescence pathway	Journal of Biological Chemistry. 2012 Jun 29;287(27):22533-22548.
2011-11	A novel RING finger protein, Znf179, modulates cell cycle exit and neuronal differentiation of P19 embryonal carcinoma cells	Cell Death and Differentiation. 2011 Nov;18(11):1791-1804.
2011-05	Selective inhibition of early-but not late-expressed HIF-1alpha is neuroprotective in rats after focal ischemic brain damage	Brain Pathology. 2011 May;21(3):249-262.

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