國家衛生研究院 NHRI:Item 3990099045/4846
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    題名: A novel approach to identify the thermal mechanism in high- and low- frequency focused ultrasound thermal ablation process
    其他題名: 6th International Symposium on Therapeutic Ultrasound
    作者: Liu, H;Chen, Y;Chen, W;Shih, T;Chen, J;Lin, W
    貢獻者: Division of Medical Engineering Research
    摘要: The purpose of this study is to propose a novel approach to identify the thermal mechanism during the high- and low- frequency focused ultrasound thermal ablation process, and to verify that the occurrence of the ultrasound-induced macroscopically visible bubbles exert another key effect in thermal lesion formation during the focused ultrasound thermal ablation process. In our experiments, consecutive sonications with orthogonal intersections were applied to observe the thermal lesion interaction induced by 577- or 1155-kHz ultrasound. Results showed that the 1155-kHz heating was dominated by ultrasound energy absorption, with blocking of consecutive sonications being evident only rarely. However, in 577-kHz sonications, the thermal process was dominated by inertial cavitation and the corresponding ultrasound-induced macroscopic visible bubbles, which was verified form the later lesion been blocked by the former one and direct observation from light microscopy. This study demonstrates that the operating frequency for ultrasound thermal ablation should be selected based on the intended specific thermal mechanisms to be induced.
    日期: 2007-05
    關聯: 6th International Symposium on Therapeutic Ultrasound. 2007 May;911:144-149.
    Link to: http://dx.doi.org/10.1063/1.2744265
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000247342200023
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=34548707895
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