國家衛生研究院 NHRI:Item 3990099045/4068
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 911702      在线人数 : 940
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/4068


    题名: Enhancement of cell radiation sensitivity by pegylated gold nanoparticles
    作者: Liu, CJ;Wang, CH;Chen, ST;Chen, HH;Leng, WH;Chien, CC;Wang, CL;Kempson, IM;Hwu, Y;Lai, TC;Hsiao, M;Yang, CS;Chen, YJ;Margaritondo, G
    贡献者: Center for Nanomedicine Research
    摘要: Biocompatible Au nanoparticles with surfaces modified by PEG (polyethyleneglycol) were developed in view of possible applications for the enhancementof radiotherapy. Such nanoparticles exhibit preferential deposition at tumorsites due to the enhanced permeation and retention (EPR) effect. Here, wesystematically studied their effects on EMT-6 and CT26 cell survival ratesduring irradiation for a dose up to 10 Gy with a commercial biological irradiator(E average = 73 keV), a Cu-Kα 1 x-ray source (8.048 keV), a monochromatizedsynchrotron source (6.5 keV), a radio-oncology linear accelerator (6 MeV) anda proton source (3 MeV). The percentage of surviving cells after irradiationwas found to decrease by ∼ 2–45% in the presence of PEG-Au nanoparticles([Au] = 400, 500 or 1000 μM). The cell survival rates decreased as a functionof the dose for all sources and nanoparticle concentrations. These resultscould open the way to more effective cancer irradiation therapies by usingnanoparticles with optimized surface treatment. Difficulties in applying MTTassays were also brought to light, showing that this approach is not suitable forradiobiology.
    日期: 2010-02
    關聯: Physics in Medicine and Biology. 2010 Feb;55(4):931-945.
    Link to: http://dx.doi.org/10.1088/0031-9155/55/4/002
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0031-9155&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000274206800002
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=76149129758
    显示于类别:[楊重熙] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    SCP76149129758.pdf1268KbAdobe PDF233检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈