國家衛生研究院 NHRI:Item 3990099045/4068

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Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/4068

Title:	Enhancement of cell radiation sensitivity by pegylated gold nanoparticles
Authors:	Liu, CJ;Wang, CH;Chen, ST;Chen, HH;Leng, WH;Chien, CC;Wang, CL;Kempson, IM;Hwu, Y;Lai, TC;Hsiao, M;Yang, CS;Chen, YJ;Margaritondo, G
Contributors:	Center for Nanomedicine Research
Abstract:	Biocompatible Au nanoparticles with surfaces modiﬁed by PEG (polyethyleneglycol) were developed in view of possible applications for the enhancementof radiotherapy. Such nanoparticles exhibit preferential deposition at tumorsites due to the enhanced permeation and retention (EPR) effect. Here, wesystematically studied their effects on EMT-6 and CT26 cell survival ratesduring irradiation for a dose up to 10 Gy with a commercial biological irradiator(E average = 73 keV), a Cu-Kα 1 x-ray source (8.048 keV), a monochromatizedsynchrotron source (6.5 keV), a radio-oncology linear accelerator (6 MeV) anda proton source (3 MeV). The percentage of surviving cells after irradiationwas found to decrease by ∼ 2–45% in the presence of PEG-Au nanoparticles([Au] = 400, 500 or 1000 μM). The cell survival rates decreased as a functionof the dose for all sources and nanoparticle concentrations. These resultscould open the way to more effective cancer irradiation therapies by usingnanoparticles with optimized surface treatment. Difﬁculties in applying MTTassays were also brought to light, showing that this approach is not suitable forradiobiology.
Date:	2010-02
Relation:	Physics in Medicine and Biology. 2010 Feb;55(4):931-945.
Link to:	http://dx.doi.org/10.1088/0031-9155/55/4/002
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0031-9155&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000274206800002
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=76149129758
Appears in Collections:	[Chung-Shi Yang] Periodical Articles

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