國家衛生研究院 NHRI:Item 3990099045/3865

NHRI > Institute of Biotechnology and Pharmaceutical Research > Jyh-Haur Chern > Periodical Articles > Item 3990099045/3865

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/3865

Title:	Design and efficient synthesis of novel arylthiourea derivatives as potent hepatitis C virus inhibitors
Authors:	Kang, IJ;Wang, LW;Hsu, SJ;Lee, CC;Lee, YC;Wu, YS;Yueh, A;Wang, JC;Hsu, TA;Chao, YS;Chern, JH
Contributors:	Division of Biotechnology and Pharmaceutical Research
Abstract:	A novel class of arylthiourea HCV inhibitors bearing various functionalities, such as cyclic urea, cyclic thiourea, urea, and thiourea, on the alkyl linker were designed and synthesized. Herein we report the synthesis and structure-activity relationships (SARs) of this novel class of arylthiourea derivatives that showed potent inhibitory activities against HCV in the cell-based subgenomic HCV replicon assay. Among compounds tested, the new carbazole derivative 64, which has an eight-carbon linkage between the phenyl and carbazole rings and a tolyl group at the N-9 position of carbazole, was found to possess strong anti-HCV activity (EC50 = 0.031 μM), lower cytotoxicity (CC50 >50 μM), and higher selectivity index (SI >1612) compared to its derivatives.
Date:	2009-11-01
Relation:	Bioorganic and Medicinal Chemistry Letters. 2009 Nov 1;19(21):6063-6068.
Link to:	http://dx.doi.org/10.1016/j.bmcl.2009.09.037
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0960-894X&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000270561300016
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=72049097165
Appears in Collections:	[Jyh-Haur Chern] Periodical Articles [Yu-Sheng Chao(2002-2013)] Periodical Articles [John Tsu-An Hsu] Periodical Articles [Yueh Andrew Yueh] Periodical Articles

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