國家衛生研究院 NHRI:Item 3990099045/3836
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    题名: IL-6-transfected tumor cells modulate the status of CD8+ and CD4+ T cells to control tumor growth
    作者: Hsieh, CL;Liu, SJ;Shen, CR;Chen, MY;Hsu, SC;Tsai, JP;Li, YS;Yang, CJ;Chong, P;Chen, HW
    贡献者: Vaccine Research and Development Center
    摘要: IL-6 is a proinflammatory cytokine secreted by tumor cells and immune cells to affect the development of cancer. This study demonstrates the effects of tumor-derived IL-6 on the malignancy of tumor cells and tumor immunity. The tumor cell line, EG7, was transfected with a mammalian expression vector encoding the full length of murine IL-6 to mimic IL-6-secreting tumor cells. Two IL-6 transfectants with low and high IL-6 production were compared in vitro and in vivo. While the in vitro proliferation rates of both transfectants and the parental line were similar, high expression of IL-6 induced a significant reduction in tumor growth in vivo. Concomitantly, there was an increase in IFN-γ positive tumor-infiltrating lymphocytes and a decrease in the suppressive CD4+CD25+FoxP3+ population. These results demonstrate the direct effects of tumor-derived IL-6 on cancer development and the induction of tumor immunity.
    日期: 2010-06
    關聯: Immunobiology. 2010 Jun;215(6):486-491.
    Link to: http://dx.doi.org/10.1016/j.imbio.2009.07.003
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0171-2985&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000278826000007
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77952541868
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