國家衛生研究院 NHRI:Item 3990099045/3836

NHRI > National Institute of Infectious Diseases and Vaccinology > Hsin-Wei Chen > Periodical Articles > Item 3990099045/3836

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/3836

Title:	IL-6-transfected tumor cells modulate the status of CD8+ and CD4+ T cells to control tumor growth
Authors:	Hsieh, CL;Liu, SJ;Shen, CR;Chen, MY;Hsu, SC;Tsai, JP;Li, YS;Yang, CJ;Chong, P;Chen, HW
Contributors:	Vaccine Research and Development Center
Abstract:	IL-6 is a proinflammatory cytokine secreted by tumor cells and immune cells to affect the development of cancer. This study demonstrates the effects of tumor-derived IL-6 on the malignancy of tumor cells and tumor immunity. The tumor cell line, EG7, was transfected with a mammalian expression vector encoding the full length of murine IL-6 to mimic IL-6-secreting tumor cells. Two IL-6 transfectants with low and high IL-6 production were compared in vitro and in vivo. While the in vitro proliferation rates of both transfectants and the parental line were similar, high expression of IL-6 induced a significant reduction in tumor growth in vivo. Concomitantly, there was an increase in IFN-γ positive tumor-infiltrating lymphocytes and a decrease in the suppressive CD4+CD25+FoxP3+ population. These results demonstrate the direct effects of tumor-derived IL-6 on cancer development and the induction of tumor immunity.
Date:	2010-06
Relation:	Immunobiology. 2010 Jun;215(6):486-491.
Link to:	http://dx.doi.org/10.1016/j.imbio.2009.07.003
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0171-2985&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000278826000007
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77952541868
Appears in Collections:	[Hsin-Wei Chen] Periodical Articles [Shih-Jen Liu] Periodical Articles [Pele Choi-Sing Chong] Periodical Articles [Shu-Ching Hsu] Periodical Articles

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