國家衛生研究院 NHRI:Item 3990099045/3551

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Title:	Design, synthesis, and anti-HCV activity of thiourea compounds
Authors:	Kang, IJ;Wang, LW;Lee, CC;Lee, YC;Chao, YS;Hsu, TA;Chern, JH
Contributors:	Division of Biotechnology and Pharmaceutical Research
Abstract:	A series of thiourea derivatives were synthesized and their antiviral activity was evaluated in a cell-based HCV subgenomic replicon assay. SAR studies revealed that the chain length and the position of the alkyl linker largely influenced the in vitro anti-HCV activity of this class of potent antiviral agents. Among this series of compounds synthesized, the thiourea derivative with a six-carbon alkyl linker at the meta-position of the central phenyl ring (10) was identified as the most potent anti-HCV inhibitor (EC50 = 0.047 μM) with a selectivity index of 596. ? 2009 Elsevier Ltd. All rights reserved.
Date:	2009-04-01
Relation:	Bioorganic and Medicinal Chemistry Letters. 2009 Apr 1;19(7):1950-1955.
Link to:	http://dx.doi.org/10.1016/j.bmcl.2009.02.048
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0960-894X&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000264169700024
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=62149108591
Appears in Collections:	[Jyh-Haur Chern] Periodical Articles [John Tsu-An Hsu] Periodical Articles [Yu-Sheng Chao(2002-2013)] Periodical Articles

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