國家衛生研究院 NHRI:Item 3990099045/3388
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 856821      在线人数 : 925
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/3388


    题名: Analogues of 2-phenyl-ethenesulfonic acid phenyl ester have dual functions of inhibiting expression of inducible nitric oxide synthase and activating peroxisome proliferator-activated receptor gamma
    其它题名: Analogues of 2-phenyl-ethenesulfonic acid phenyl ester have dual functions of inhibiting expression of inducible nitric oxide synthase and activating peroxisome proliferator-activated receptor γ
    作者: Lee, YZ;Yang, CW;Kang, IJ;Wu, SH;Chao, YS;Chern, JH;Lee, SJ
    贡献者: Division of Biotechnology and Pharmaceutical Research
    摘要: We identified a series of 2-phenyl-ethenesulfonic acid phenyl ester analogues as novel dual-function agents that suppressed nitric oxide production in lipopolysaccharide/interferon γ-stimulated RAW264.7 cells and activated peroxisome proliferator-activated receptor γ (PPARγ) in a cell-based transactivation assay. Western blot analysis demonstrated that these compounds inhibit the expression of inducible nitric oxide synthase protein, and scintillation proximity assay validated their ability to bind to PPARγ. Our studies provide the basis for developing these dual-function agents for anti-inflammation and anti-atherosclerosis therapy. ? 2008 Elsevier Ltd. All rights reserved.
    日期: 2008-10-15
    關聯: Bioorganic and Medicinal Chemistry Letters. 2008 Oct 15;18(20):5676-5679.
    Link to: http://dx.doi.org/10.1016/j.bmcl.2008.08.107
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0960-894X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000259972800077
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=53549113033
    显示于类别:[李秀珠] 期刊論文
    [陳志豪] 期刊論文
    [趙宇生(2002-2013)] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    SCP53549113033.pdf239KbAdobe PDF1044检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈