國家衛生研究院 NHRI:Item 3990099045/3081
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    题名: Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 2: Isoindoline containing inhibitors
    作者: Van Goethem, S;Van der Veken, P;Dubois, V;Soroka, A;Lambeir, AM;Chen, X;Haemers, A;Scharpe, S;De Meester, I;Augustyns, K
    贡献者: Division of Biotechnology and Pharmaceutical Research
    摘要: To obtain selective and potent inhibitors of dipeptidyl peptidases 8 and 9, we synthesized a series of substituted isoindolines as modified analogs of allo-Ile-isoindoline, the reference DPP8/9 inhibitor. The influence of phenyl substituents and different P2 residues on the inhibitors' affinity toward other DPPs and more specifically, their potential to discriminate between DPP8 and DPP9 will be discussed. Within this series compound 8j was shown to be a potent and selective inhibitor of DPP8/9 with low activity toward DPP II. 2008 Elsevier Ltd. All rights reserved.
    关键词: Chemistry, Medicinal;Chemistry, Organic
    日期: 2008-07-15
    關聯: Bioorganic and Medicinal Chemistry Letters. 2008 Jul;18(14):4159-4162.
    Link to: http://dx.doi.org/10.1016/j.bmcl.2008.05.079
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0960-894X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000257640400075
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=47149101598
    显示于类别:[陳新(2002-2015)] 期刊論文

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