國家衛生研究院 NHRI:Item 3990099045/3081

NHRI > Institute of Biotechnology and Pharmaceutical Research > Xin Chen(2002-2015) > Periodical Articles > Item 3990099045/3081

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/3081

Title:	Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 2: Isoindoline containing inhibitors
Authors:	Van Goethem, S;Van der Veken, P;Dubois, V;Soroka, A;Lambeir, AM;Chen, X;Haemers, A;Scharpe, S;De Meester, I;Augustyns, K
Contributors:	Division of Biotechnology and Pharmaceutical Research
Abstract:	To obtain selective and potent inhibitors of dipeptidyl peptidases 8 and 9, we synthesized a series of substituted isoindolines as modified analogs of allo-Ile-isoindoline, the reference DPP8/9 inhibitor. The influence of phenyl substituents and different P2 residues on the inhibitors' affinity toward other DPPs and more specifically, their potential to discriminate between DPP8 and DPP9 will be discussed. Within this series compound 8j was shown to be a potent and selective inhibitor of DPP8/9 with low activity toward DPP II. 2008 Elsevier Ltd. All rights reserved.
Keywords:	Chemistry, Medicinal;Chemistry, Organic
Date:	2008-07-15
Relation:	Bioorganic and Medicinal Chemistry Letters. 2008 Jul;18(14):4159-4162.
Link to:	http://dx.doi.org/10.1016/j.bmcl.2008.05.079
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0960-894X&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000257640400075
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=47149101598
Appears in Collections:	[Xin Chen(2002-2015)] Periodical Articles

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