國家衛生研究院 NHRI:Item 3990099045/2954
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    题名: Prognostic implications of the expression of erbB2, topoisomerase II alpha and thymidylate synthase in metastatic gastric cancer after fluorouracil-based therapy
    作者: Liu, JM;Chen, LT;Li, AFY;Wu, CW;Lan, C;Chung, TR;Shiah, HS;Lee, KD;Liu, TW;Whang-Peng, J
    贡献者: National Institute of Cancer Research
    摘要: Objective: This retrospective study aimed to ascertain the expression of erbB2 in relation to topoisomerase IIalpha (T2alpha) and thymidylate synthase (TS) markers in 30 consecutive metastatic gastric cancer patients with a specimen available for study. Methods: All patients had been entered on consecutive chemotherapeutic clinical trials that were all 5-fluorouracil based. The specimens were evaluated by fluorescence in situ hybridization to ascertain erbB2 and T2alpha gene amplification, and by immunohistochemical staining for T2alpha and TS protein expression. Results: erbB2 amplification was detected in 16.7% of specimens. with co-amplification of the T2alpha gene in 40%, and 44% had undetectable TS protein expression. Kaplan-Meier survival curves showed significantly prolonged overall survival in patients with erbB2 and T2alpha gene amplification, T2alpha protein overexpression and absence of TS protein expression (P = 0.0011, P = 0.0048, P = 0.0061 and P = 0.0267, respectively, by log rank test). There was a positive correlation between erbB2 amplification and T2alpha amplification, T2alpha: protein overexpression. and a trend towards absence of TS expression (P = 0.0001. P = 0.003 and P = 0.066 by Fisher's exact test). Conclusion: High dose fluorouracil/leucovorin-based chemotherapy may have the potential to reverse the adverse effects resulting from erbB2 gene amplification in gastric cancer.
    关键词: Oncology
    日期: 2004-12
    關聯: Japanese Journal of Clinical Oncology. 2004 Dec;34(12):727-732.
    Link to: http://dx.doi.org/10.1093/jjco/hyh137
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0368-2811&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000226624400004
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=14544297976
    显示于类别:[彭汪嘉康(1996-2007)] 期刊論文
    [劉敏(1996-2007)] 期刊論文
    [劉滄梧] 期刊論文
    [夏和雄(1996-2012)] 期刊論文
    [陳立宗] 期刊論文
    [李冠德(1997-2004)] 期刊論文

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