國家衛生研究院 NHRI:Item 3990099045/2954

NHRI > National Institute of Cancer Research > Jacqueline Whang-Peng(1996-2007) > Periodical Articles > Item 3990099045/2954

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Title:	Prognostic implications of the expression of erbB2, topoisomerase II alpha and thymidylate synthase in metastatic gastric cancer after fluorouracil-based therapy
Authors:	Liu, JM;Chen, LT;Li, AFY;Wu, CW;Lan, C;Chung, TR;Shiah, HS;Lee, KD;Liu, TW;Whang-Peng, J
Contributors:	National Institute of Cancer Research
Abstract:	Objective: This retrospective study aimed to ascertain the expression of erbB2 in relation to topoisomerase IIalpha (T2alpha) and thymidylate synthase (TS) markers in 30 consecutive metastatic gastric cancer patients with a specimen available for study. Methods: All patients had been entered on consecutive chemotherapeutic clinical trials that were all 5-fluorouracil based. The specimens were evaluated by fluorescence in situ hybridization to ascertain erbB2 and T2alpha gene amplification, and by immunohistochemical staining for T2alpha and TS protein expression. Results: erbB2 amplification was detected in 16.7% of specimens. with co-amplification of the T2alpha gene in 40%, and 44% had undetectable TS protein expression. Kaplan-Meier survival curves showed significantly prolonged overall survival in patients with erbB2 and T2alpha gene amplification, T2alpha protein overexpression and absence of TS protein expression (P = 0.0011, P = 0.0048, P = 0.0061 and P = 0.0267, respectively, by log rank test). There was a positive correlation between erbB2 amplification and T2alpha amplification, T2alpha: protein overexpression. and a trend towards absence of TS expression (P = 0.0001. P = 0.003 and P = 0.066 by Fisher's exact test). Conclusion: High dose fluorouracil/leucovorin-based chemotherapy may have the potential to reverse the adverse effects resulting from erbB2 gene amplification in gastric cancer.
Keywords:	Oncology
Date:	2004-12
Relation:	Japanese Journal of Clinical Oncology. 2004 Dec;34(12):727-732.
Link to:	http://dx.doi.org/10.1093/jjco/hyh137
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0368-2811&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000226624400004
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=14544297976
Appears in Collections:	[Jacqueline Whang-Peng(1996-2007)] Periodical Articles [Ming Jacqueline Liu(1996-2007)] Periodical Articles [Tsang-Wu Liu] Periodical Articles [Her-Shyong Shiah(1996-2012)] Periodical Articles [Li-Tzong Chen] Periodical Articles [Kuan-Te Li(1997-2004)] Periodical Articles

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