國家衛生研究院 NHRI:Item 3990099045/2731
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/2731


    Title: 7-aroyl-aminoindoline-1-sulfonamides as a novel class of potent antitubulin agents
    Authors: Chang, JY;Hsieh, HP;Chang, CY;Hsu, KS;Chiang, YF;Chen, CM;Kuo, CC;Liou, JP
    Contributors: National Institute of Cancer Research;Institute of Biotechnology and Pharmaceutical Research
    Abstract: A novel series of 7-aroyl-aminoindoline-1-benzenesulfonamides showed excellent activity as inhibitors of tubulin polymerization through binding with the colchicine binding site of microtubules. Compound 15 and 16 display IC50 values of 1.1 and 1.2 mu M, respectively. Compound 15 inhibited the human cancer cell growth of KB, MKN45, H460, HT29, and TSGH, as well as one human-resistant cancer line of KB-vin 10, with an IC50 of 9.6, 8.8, 9.4, 8.6, 10.8, and 8.9 nM, respectively.
    Keywords: Chemistry, Medicinal
    Date: 2006-11-16
    Relation: Journal of Medicinal Chemistry. 2006 Nov;49(23):6656-6659.
    Link to: http://dx.doi.org/10.1021/jm061076u
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0022-2623&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000241894000008
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33750976393
    Appears in Collections:[Jang-Yang Chang] Periodical Articles
    [Hsing-Pang Hsieh] Periodical Articles
    [Ching-Chuan Kuo] Periodical Articles

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