國家衛生研究院 NHRI:Item 3990099045/2731
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    題名: 7-aroyl-aminoindoline-1-sulfonamides as a novel class of potent antitubulin agents
    作者: Chang, JY;Hsieh, HP;Chang, CY;Hsu, KS;Chiang, YF;Chen, CM;Kuo, CC;Liou, JP
    貢獻者: National Institute of Cancer Research;Institute of Biotechnology and Pharmaceutical Research
    摘要: A novel series of 7-aroyl-aminoindoline-1-benzenesulfonamides showed excellent activity as inhibitors of tubulin polymerization through binding with the colchicine binding site of microtubules. Compound 15 and 16 display IC50 values of 1.1 and 1.2 mu M, respectively. Compound 15 inhibited the human cancer cell growth of KB, MKN45, H460, HT29, and TSGH, as well as one human-resistant cancer line of KB-vin 10, with an IC50 of 9.6, 8.8, 9.4, 8.6, 10.8, and 8.9 nM, respectively.
    關鍵詞: Chemistry, Medicinal
    日期: 2006-11-16
    關聯: Journal of Medicinal Chemistry. 2006 Nov;49(23):6656-6659.
    Link to: http://dx.doi.org/10.1021/jm061076u
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0022-2623&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000241894000008
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33750976393
    顯示於類別:[張俊彥] 期刊論文
    [謝興邦] 期刊論文
    [郭靜娟] 期刊論文

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