國家衛生研究院 NHRI:Item 3990099045/2658
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    題名: Expression of Axl in lung adenocarcinoma and correlation with tumor progression
    作者: Shieh, YS;Lai, CY;Kao, YR;Shiah, SG;Chu, YW;Lee, HS;Wu, CW
    貢獻者: National Institute of Cancer Research
    摘要: We used the Transwell system to select highly invasive cell lines from minimally invasive parent cells, and we compared gene expression in paired cell lines with high and low invasive potentials. AxI was relatively overexpressed in the highly invasive cell lines when compared with their minimally invasive counterparts. However, there is only limited information about the role of AxI in cancer invasion. The biologic function of AxI in tumor invasion was investigated by overexpression of full-length AxI in minimally invasive cells and by siRNA knockdown of AxI expression in highly invasive cells. Overexpression of AxI in minimally invasive cells increased their invasiveness. siRNA reduced cell invasiveness as AxI was downregulated in highly invasive cells. We further investigated the protein expression of AxI by immunohistochemistry and its correlation with clinicopathologic features. Data from a study of 58 patient specimens showed that AxI immunoreactivity was statistically significant with respect to lymph node status (P < .0001) and the patient's clinical stage (P < .0001). Our results demonstrate that AxI protein kinase seems to play an important role in the invasion and progression of lung cancer.
    關鍵詞: Oncology
    日期: 2005-12
    關聯: Neoplasia. 2005 Dec;7(12):1058-1064.
    Link to: http://dx.doi.org/10.1593/neo.05640
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1476-5586&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000234460100004
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33644876133
    顯示於類別:[吳成文(1996-2008)] 期刊論文
    [夏興國] 期刊論文

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