國家衛生研究院 NHRI:Item 3990099045/2658
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/2658


    Title: Expression of Axl in lung adenocarcinoma and correlation with tumor progression
    Authors: Shieh, YS;Lai, CY;Kao, YR;Shiah, SG;Chu, YW;Lee, HS;Wu, CW
    Contributors: National Institute of Cancer Research
    Abstract: We used the Transwell system to select highly invasive cell lines from minimally invasive parent cells, and we compared gene expression in paired cell lines with high and low invasive potentials. AxI was relatively overexpressed in the highly invasive cell lines when compared with their minimally invasive counterparts. However, there is only limited information about the role of AxI in cancer invasion. The biologic function of AxI in tumor invasion was investigated by overexpression of full-length AxI in minimally invasive cells and by siRNA knockdown of AxI expression in highly invasive cells. Overexpression of AxI in minimally invasive cells increased their invasiveness. siRNA reduced cell invasiveness as AxI was downregulated in highly invasive cells. We further investigated the protein expression of AxI by immunohistochemistry and its correlation with clinicopathologic features. Data from a study of 58 patient specimens showed that AxI immunoreactivity was statistically significant with respect to lymph node status (P < .0001) and the patient's clinical stage (P < .0001). Our results demonstrate that AxI protein kinase seems to play an important role in the invasion and progression of lung cancer.
    Keywords: Oncology
    Date: 2005-12
    Relation: Neoplasia. 2005 Dec;7(12):1058-1064.
    Link to: http://dx.doi.org/10.1593/neo.05640
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1476-5586&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000234460100004
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33644876133
    Appears in Collections:[Cheng-Wen Wu(1996-2008)] Periodical Articles
    [Shine-Gwo Shiah] Periodical Articles

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