國家衛生研究院 NHRI:Item 3990099045/2523
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    题名: G-2548A polymorphism of the leptin gene is correlated with extreme obesity in Taiwanese aborigines
    作者: Wang, TN;Huang, MC;Chang, WT;Ko, AMS;Tsai, EM;Liu, CS;Lee, CH;Ko, YC
    贡献者: Division of Environmental Health and Occupational Medicine
    摘要: We examined the genetic associations of the G-2548A polymorphism in the promoter of the leptin (LEP) gene and the Gln223Arg (Q223R) polymorphism of the leptin receptor (LEPR) gene with obesity. Two hundred twenty-six obese aboriginal subjects (BMI >= 27 kg/m(2)) and 182 aboriginal subjects with normal weight (BMI < 25 kg/m(2)) participated in this study. The polymorphisms of LEP G-2548A and LEPR Q223R were genotyped by polymerase chain reaction/restriction fragment length polymorphism, and their anthropometric characteristics were measured. Levels of leptin, triglycerides, and cholesterol were measured after overnight fasting. We found that the frequencies of the LEP G/G homozygote (22.6%) with Mendelian recessive (chi(2) = 7.89, p = 0.005) and codominant (chi(2) = 7.93, p = 0.02) models to be higher in the extremely obese subjects (BMI >=_ 35 kg/m(2)) than in normal weight subjects (6.9%) but not in moderately obese subjects (35 > BMI >= 27 kg/m(2)). There was no difference in genotypic frequency of the LEPR Q223R polymorphism between the extreme obese and control groups. We suggest that the LEP -2548 G/G homozygote plays a genetic recessive role in the development of extreme obesity in Taiwanese aborigines.
    关键词: Endocrinology & Metabolism;Nutrition & Dietetics
    日期: 2006-02
    關聯: Obesity. 2006 Feb;14(2):183-187.
    Link to: http://dx.doi.org/10.1038/oby.2006.23
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1930-7381&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000238448000001
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33748194234
    显示于类别:[葛應欽(2003-2009)] 期刊論文

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