國家衛生研究院 NHRI:Item 3990099045/2523

NHRI > National Institute of Environmental Health Sciences > Ying-Chin Ko(2003-2009) > Periodical Articles > Item 3990099045/2523

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/2523

Title:	G-2548A polymorphism of the leptin gene is correlated with extreme obesity in Taiwanese aborigines
Authors:	Wang, TN;Huang, MC;Chang, WT;Ko, AMS;Tsai, EM;Liu, CS;Lee, CH;Ko, YC
Contributors:	Division of Environmental Health and Occupational Medicine
Abstract:	We examined the genetic associations of the G-2548A polymorphism in the promoter of the leptin (LEP) gene and the Gln223Arg (Q223R) polymorphism of the leptin receptor (LEPR) gene with obesity. Two hundred twenty-six obese aboriginal subjects (BMI >= 27 kg/m(2)) and 182 aboriginal subjects with normal weight (BMI < 25 kg/m(2)) participated in this study. The polymorphisms of LEP G-2548A and LEPR Q223R were genotyped by polymerase chain reaction/restriction fragment length polymorphism, and their anthropometric characteristics were measured. Levels of leptin, triglycerides, and cholesterol were measured after overnight fasting. We found that the frequencies of the LEP G/G homozygote (22.6%) with Mendelian recessive (chi(2) = 7.89, p = 0.005) and codominant (chi(2) = 7.93, p = 0.02) models to be higher in the extremely obese subjects (BMI >=_ 35 kg/m(2)) than in normal weight subjects (6.9%) but not in moderately obese subjects (35 > BMI >= 27 kg/m(2)). There was no difference in genotypic frequency of the LEPR Q223R polymorphism between the extreme obese and control groups. We suggest that the LEP -2548 G/G homozygote plays a genetic recessive role in the development of extreme obesity in Taiwanese aborigines.
Keywords:	Endocrinology & Metabolism;Nutrition & Dietetics
Date:	2006-02
Relation:	Obesity. 2006 Feb;14(2):183-187.
Link to:	http://dx.doi.org/10.1038/oby.2006.23
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1930-7381&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000238448000001
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33748194234
Appears in Collections:	[Ying-Chin Ko(2003-2009)] Periodical Articles

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