| 2024-10-29 |
DBPR116, a prodrug of BPRMU191, in combination with naltrexone as a safer opioid analgesic than morphine via peripheral administration |
Journal of Medicinal Chemistry. 2024 Oct 29;Article in Press. |
 |
| 2024-07-17 |
Discovery of a mu-opioid receptor modulator that in combination with morphinan antagonists induces analgesia |
Cell Chemical Biology. 2024 Jul 17;Article in Press. |
|
| 2024-07-04 |
Development of a humanized antibody targeting extracellular HSP90alpha to suppress endothelial-mesenchymal transition-enhanced tumor growth of pancreatic adenocarcinoma cells |
Cells. 2024 Jul 04;13(13):Article number 1146. |
|
| 2024-06-24 |
Discovery of dual MER/AXL kinase inhibitors as bifunctional small molecules for inhibiting tumor growth and enhancing tumor immune microenvironment |
Journal of Medicinal Chemistry. 2024 Jun 24;Article in Press. |
|
| 2024-06-01 |
Discovery of a long half-life AURKA inhibitor to treat MYC-amplified solid tumors as a monotherapy and in combination with everolimus |
Molecular Cancer Therapeutics. 2024 Jun 01;23(6):766-779. |
|
| 2023-10-05 |
Discovery of tetrasubstituted thiophenes as Cisd2 activators: A potential novel therapeutic option in nonalcoholic fatty liver disease |
European Journal of Medicinal Chemistry. 2023 Oct 05;258:Article number 115583. |
|
| 2023-10-05 |
A dual nociceptin and mu opioid receptor agonist exhibited robust antinociceptive effect with decreased side effects |
European Journal of Medicinal Chemistry. 2023 Oct 05;258:Article number 115608. |
|
| 2023-10 |
Discovery of novel AXL and MER inhibitors as potential anticancer and immune modulator drugs |
Annals of Oncology. 2023 Oct;34(Suppl. 2):S214. |
|
| 2023-02-07 |
Development of furanopyrimidine-based orally active third-generation EGFR inhibitors for the treatment of non-small cell lung cancer |
Journal of Medicinal Chemistry. 2023 Feb 7;66(4):2566-2588. |
|
| 2022-12-05 |
Benzo[b]thiophene-2-carboxamides as novel opioid receptor agonists with potent analgesic effect and reduced constipation |
European Journal of Medicinal Chemistry. 2022 Dec 5;243:Article number 114728. |
|
| 2022-12-05 |
2,6-Difluorobenzamide derivatives as store-operated calcium channel (SOC) inhibitors |
European Journal of Medicinal Chemistry. 2022 Dec 5;243:Article number 114773. |
|
| 2022-10-13 |
Targeting the phosphatidylserine-immune checkpoint with a small-molecule maytansinoid conjugate |
Journal of Medicinal Chemistry. 2022 Oct 13;65(19):12802-12824. |
|
| 2022-10-03 |
Protective effect of CXCR4 antagonist DBPR807 against ischemia-reperfusion injury in a rat and porcine model of myocardial infarction: Potential adjunctive therapy for percutaneous coronary intervention |
International Journal of Molecular Sciences. 2022 Oct 3;23(19):Article number 11730. |
|
| 2022-07-24 |
Hesperetin promotes longevity and delays aging via activation of Cisd2 in naturally aged mice |
Journal of Biomedical Science. 2022 Jul 24;29:Article number 53. |
|
| 2022-07 |
Rejuvenating hepatic tumor microenvironment immunity with a phosphatidylserine-targeting small molecule drug conjugate |
Biomedicine and Pharmacotherapy. 2022 Jul;151:Article number 113084. |
|
| 2022-06-21 |
Synthesis and evaluation of small molecule drug conjugates harnessing thioester-linked maytansinoids |
Pharmaceutics. 2022 Jun 21;14(7):Article number 1316. |
|
| 2022-03-02 |
Discovery of potential neuroprotective agents against paclitaxel-induced peripheral neuropathy |
Journal of Medicinal Chemistry. 2022 Mar 2;65(6):4767-4782. |
|
| 2022-02-15 |
Click chemistry and multicomponent reaction for linker diversification of zinc dipicolylamine-based drug conjugates |
Frontiers in Chemistry. 2022 Feb 15;9:Article number 822587. |
|
| 2022-02-05 |
Discovery and development of a novel N-(3-bromophenyl)-{[(phenylcarbamoyl)amino]methyl}-N-hydroxythiophene-2-carboximidamide indoleamine 2,3-dioxygenase inhibitor using knowledge-based drug design |
European Journal of Medicinal Chemistry. 2022 Feb 5;229:Article number 114043. |
|
| 2021-11-15 |
Design and synthesis of novel orally selective and type II pan-TRK inhibitors to overcome mutations by property-driven optimization |
European Journal of Medicinal Chemistry. 2021 Nov 15;224:Article number 113673. |
|
| 2021-10-14 |
Discovery of BPR1R024, an orally active and selective CSF1R inhibitor that exhibits antitumor and immunomodulatory activity in a murine colon tumor model |
Journal of Medicinal Chemistry. 2021 Oct 14;64(19):14477-14497. |
|
| 2021-08-01 |
DBPR108, a novel dipeptidyl peptidase-4 inhibitor with antihyperglycemic activity |
Life Sciences. 2021 Aug 1;278:Article number 119574. |
|
| 2021-05-19 |
Discovery and synthesis of a pyrimidine-based aurora kinase inhibitor to reduce levels of MYC oncoproteins |
Journal of Medicinal Chemistry. 2021 May 19;64(11):7312-7330. |
|
| 2021-03-30 |
A highly selective and potent CXCR4 antagonist for hepatocellular carcinoma treatment |
Proceedings of the National Academy of Sciences of the United States of America. 2021 Mar 30;118(13):Article number e2015433118. |
|
| 2021-01 |
Overcoming vincristine resistance in cancer: Computational design and discovery of piperine-inspired P-glycoprotein inhibitors |
Chemical Biology and Drug Design. 2021 Jan;97(1):51-66. |
|
| 2021-01 |
BPRDP056, a novel small molecule drug conjugate specifically targeting phosphatidylserine for cancer therapy |
Translational Oncology. 2021 Jan;14(1):Article number 100897. |
|
| 2021-01 |
Potent and orally active purine-based fetal hemoglobin inducers for treating Beta-thalassemia and sickle cell disease |
European Journal of Medicinal Chemistry. 2021 Jan;209:Article number 112938. |
|
| 2020-08 |
Artificial intelligence approach fighting COVID-19 with repurposing drugs |
Biomedical Journal. 2020 Aug;43(4):355-362. |
|
| 2020-08 |
Repurposing old drugs as antiviral agents for coronaviruses |
Biomedical Journal. 2020 Aug;43(4):368-374. |
|
| 2020-08 |
BPR6K609: An Aurora kinase inhibitor targeting small cell lung cancer with MYC amplification |
Cancer Research. 2020 Aug;80(16):1937. |
|
| 2020-05 |
Drug-like property optimization: Discovery of orally bioavailable quinazoline-based multi-targeted kinase inhibitors |
Bioorganic Chemistry. 2020 May;98:Article number 103689. |
|
| 2020-04 |
BPR1M97, a dual mu opioid receptor/nociceptin-orphanin FQ peptide receptor agonist, produces potent antinociceptive effects with safer properties than morphine |
Neuropharmacology. 2020 Apr;166:Article number 107678. |
|
| 2020-02-18 |
Impacts of intralipid on nanodrug abraxane therapy and on the innate immune system |
Scientific Reports. 2020 Feb 18;10:Article number 2838. |
|
| 2020-02-10 |
Unique sulfur-aromatic interactions contribute to the binding of potent imidazothiazole indoleamine 2,3-Dioxygenase inhibitors |
Journal of Medicinal Chemistry. 2020 Feb 10;63(4):1642-1659. |
|
| 2020-02-01 |
Protective effects of 10,11-dihydro-5H-dibenzo[b,f]azepine hydroxamates on vascular cognitive impairment |
European Journal of Medicinal Chemistry. 2020 Feb 1;187:Article number 111915. |
|
| 2019-12 |
Identification of a multitargeted tyrosine kinase inhibitor for the treatment of gastrointestinal stromal tumors and acute myeloid leukemia |
Journal of Medicinal Chemistry. 2019 Dec;62(24):11135-11150. |
|
| 2019-11-27 |
Discovery of a furanopyrimidine-based epidermal growth factor receptor inhibitor (DBPR112) as a clinical candidate for the treatment of non-small cell lung cancer |
Journal of Medicinal Chemistry. 2019 Nov 27;62(22):10108-10123. |
|
| 2019-10 |
Discovery of clinical candidate DBPR112, a furanopyrimidine-based epidermal growth factor receptor inhibitor for the treatment of non-small cell lung cancer |
Annals of Oncology. 2019 Oct;30(Suppl. 5):789. |
|
| 2019-07-11 |
Linker optimization and therapeutic evaluation of phosphatidylserine-targeting zinc dipicolylamine-based drug conjugates |
Journal of Medicinal Chemistry. 2019 Jul 11;62(13):6047-6062. |
|
| 2019-07 |
BPRDP056, a novel small molecule drug conjugate specifically targeting phosphatidylserine for cancer therapy |
Cancer Research. 2019 Jul;79(13, Suppl.):Abstract number 227. |
|
| 2019-07 |
An Aurora kinase inhibitor BPR6K471 inhibits tumor growth and reduces the cancer stem cell-like properties of small cell lung cancer |
Cancer Research. 2019 Jul;79(13, Suppl.):Abstract number 3851. |
|
| 2019-06-05 |
Delta-opioid receptor antagonist naltrindole reduces oxycodone addiction and constipation in mice |
European Journal of Pharmacology. 2019 Jun 5;852:265-273. |
|
| 2019-05 |
Synthesis and evaluation of novel 7H-pyrrolo-[2,3-d]pyrimidine derivatives as potential anticancer agents |
Future Medicinal Chemistry. 2019 May;11(9):959-974. |
|
| 2019-04-10 |
Discovery of Conformational Control Inhibitors Switching off the Activated c-KIT and Targeting a Broad Range of Clinically Relevant c-KIT Mutants |
Journal of Medicinal Chemistry. 2019 Apr 10;62(8):3940-3957. |
|
| 2019-04-01 |
A novel, potent, and orally bioavailable thiazole HCV NS5A inhibitor for the treatment of hepatitis C virus |
European Journal of Medicinal Chemistry. 2019 Apr 1;167:245-268. |
|
| 2019-03 |
Synthesis and biological evaluation of N-glucosyl indole derivatives as sodium-dependent glucose co-transporter 2 inhibitors |
Bioorganic Chemistry. 2019 Mar;83:520-525. |
|
| 2018-08-23 |
5-aroylindoles act as selective histone deacetylase 6 inhibitors ameliorating alzheimer's disease phenotypes |
Journal of Medicinal Chemistry. 2018 Aug 23;61(16):7087-7102. |
|
| 2018-07 |
4-Bromophenylhydrazinyl benzenesulfonylphenylureas inhibit indoleamine 2,3-dioxygenase in vitro and in vivo |
Cancer Research. 2018 Jul;78(13, Suppl.):Meeting Abstract 1664. |
|
| 2018-06-15 |
2-Aroylquinoline-5,8-diones as potent anticancer agents displaying tubulin and heat shock protein 90 (HSP90) inhibition [Erratum: Organic and Biomolecular Chemistry. 2016 Jan;14(2):716-723.] |
Organic and biomolecular chemistry. 2018 Jun 15;16:4734. |
|
| 2018-04 |
4-Bromophenylhydrazinyl benzenesulfonylphenylureas as indoleamine 2,3-dioxygenase inhibitors with in vivo target inhibition and anti-tumor efficacy |
Bioorganic Chemistry. 2018 Apr;77:600-607. |
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