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生技與藥物研究所
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DBPR116, a prodrug of BPRMU191, in ...
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Showing items 176-200 of 1008. (41 Page(s) Totally)
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Date
Title
Relation
2020-02
The cardenolides ouabain and reevesioside A promote FGF2 secretion and subsequent FGFR1 phosphorylation via converged ERK1/2 activation
Biochemical Pharmacology. 2020 Feb;172:Article number 113741.
2020-02
Design, synthesis and anticancer evaluation of beta-carboline-1-one hydantoins
Future Medicinal Chemistry. 2020 Feb;12(3):183-192.
2020-02
Tylophorine-based compounds are therapeutic in rheumatoid arthritis by targeting the caprin-1 ribonucleoprotein complex and inhibiting expression of associated c-Myc and HIF-1alpha
Pharmacological Research. 2020 Feb;152:Article number 104581.
2020-01-16
Development of a cross-conjugated vinylogous [4+2] anionic annulation and application to the total synthesis of natural antibiotic (±)-ABX
Advanced Materials. 2020 Jan 16;132(16):6602-6607.
2020-01-06
Biosynthetic engineering of the antifungal, anti-MRSA auroramycin
Microbial Cell Factories. 2020 Jan 6;19:Article number 3.
2020-01-01
Delayed intervention with a novel SGLT2 inhibitor NGI001 suppresses diet-induced metabolic dysfunction and nonalcoholic fatty liver disease in mice
British Journal of Pharmacology. 2020 Jan 1;177(2):239-253.
2020-01
Identification of novel quinoline inhibitor for EHMT2/G9a through virtual screening
Biochimie. 2020 Jan;168:220-230.
2019-12-24
ERK activation modulates cancer stemness and motility of a novel mouse oral squamous cell carcinoma cell line
Cancers. 2019 Dec 24;12(1):Article number 61.
2019-12
Lysosomal cysteine protease cathepsin S is involved in cancer cell motility by regulating store-operated Ca(2+) entry
Biochimica et Biophysica Acta. Molecular Cell Research. 2019 Dec;1866(12):Article number 118517.
2019-12
A novel flavivirus entry inhibitor, BP34610, discovered through high-throughput screening with dengue reporter viruses
Antiviral Research. 2019 Dec;172:Article number 104636.
2019-12
Progerin in muscle leads to thermogenic and metabolic defects via impaired calcium homeostasis
Aging Cell. 2019 Dec;Article number e13090.
2019-12
Identification of a multitargeted tyrosine kinase inhibitor for the treatment of gastrointestinal stromal tumors and acute myeloid leukemia
Journal of Medicinal Chemistry. 2019 Dec;62(24):11135-11150.
2019-11-27
Discovery of a furanopyrimidine-based epidermal growth factor receptor inhibitor (DBPR112) as a clinical candidate for the treatment of non-small cell lung cancer
Journal of Medicinal Chemistry. 2019 Nov 27;62(22):10108-10123.
2019-10-08
Identification of two novel small compounds that inhibit liver cancer formation in zebrafish and analysis of their conjugation to nanodiamonds to further reduce toxicity
Advanced Therapeutics. 2019 Oct 8;2(12):Article number 1900105.
2019-10
In vivo efficacy of cannabinoid receptor 1 antagonist, CPD1, in treating non-alcoholic fatty liver disease
Hepatology. 2019 Oct;70:1333A.
2019-10
Discovery of clinical candidate DBPR112, a furanopyrimidine-based epidermal growth factor receptor inhibitor for the treatment of non-small cell lung cancer
Annals of Oncology. 2019 Oct;30(Suppl. 5):789.
2019-10
The molecular mechanisms of EpCAM in regulating tumor progression and development of anti-EpCAM antibodies for colon cancer diagnosis and therapy
Annals of Oncology. 2019 Oct;30(Suppl. 5):786.
2019-10
Inhibition of Rspo-Wnt pathway facilitates checkpoint blockade therapy by anti-RSPO3 antibody (DBPR117)
Annals of Oncology. 2019 Oct;30(Suppl. 5):191.
2019-09
Effects of boschnaloside from Boschniakia rossica on dysglycemia and islet dysfunction in severely diabetic mice through modulating the action of glucagon-like peptide-1
Phytomedicine. 2019 Sep;62:Article number 152946.
2019-08-27
A dengue virus type 2 (DENV-2) NS4B-interacting host factor, SERP1, reduces DENV-2 production by suppressing viral RNA replication
Viruses. 2019 Aug 27;11(9):Article number 787.
2019-08-15
Sun1 mediates interkinetic nuclear migration and Notch signaling in the neurogenesis of zebrafish
Stem Cells and Development. 2019 Aug 15;28(16):1116-1127.
2019-08-06
Targeting a ribonucleoprotein complex containing the caprin-1 protein and the c-Myc mRNA suppresses tumor growth in mice: An identification of a novel oncotarget[Erratum: Oncotarget. 2015 Feb;6(4):2148-2163.]
Oncotarget. 2019 Aug 6;10(47):4919.
2019-08
A structure-function approach identifies L-PGDS as a mediator responsible for glucocorticoid-induced leptin expression in adipocytes
Biochemical Pharmacology. 2019 Aug;166:203-211.
2019-08
Melatonin promotes neuroblastoma cell differentiation by activating hyaluronan synthase 3-induced mitophagy
Cancer Medicine. 2019 Aug;8(10):4821-4835.
2019-07-11
Linker optimization and therapeutic evaluation of phosphatidylserine-targeting zinc dipicolylamine-based drug conjugates
Journal of Medicinal Chemistry. 2019 Jul 11;62(13):6047-6062.
Showing items 176-200 of 1008. (41 Page(s) Totally)
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