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生技與藥物研究所
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DBPR116, a prodrug of BPRMU191, in ...
Incorporating tissue-specific gene ...
Induction of thymus atrophy and dis...
Enhanced non-viral gene delivery vi...
A novel multitask learning algorith...
Discovery of a mu-opioid receptor m...
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Macrophage-mediated controlled rele...
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Date
Title
Relation
2024-10-29
DBPR116, a prodrug of BPRMU191, in combination with naltrexone as a safer opioid analgesic than morphine via peripheral administration
Journal of Medicinal Chemistry. 2024 Oct 29;Article in Press.
2024-09
Enhanced non-viral gene delivery via calcium phosphate/DNA co-precipitates with low-voltage pulse electroporation in NK-92 cells for immunocellular therapy
APL Bioengineering. 2024 Sep;8:Article number 036107.
2024-08-14
Induction of thymus atrophy and disruption of thymocyte development by fipronil through dysregulation of IL-7-associated genes
Chemical Research in Toxicology. 2024 Aug 14;Article in Press.
2024-08-02
A novel multitask learning algorithm for tasks with distinct chemical space: zebrafish toxicity prediction as an example
Journal of Cheminformatics. 2024 Aug 02;16:Article number 91.
2024-07-31
Incorporating tissue-specific gene expression data to improve chemical-disease inference of in silico toxicogenomics methods
Journal of Xenobiotics. 2024 Jul 31;14(3):1023-1035.
2024-07-17
Discovery of a mu-opioid receptor modulator that in combination with morphinan antagonists induces analgesia
Cell Chemical Biology. 2024 Jul 17;Article in Press.
2024-07-04
Development of a humanized antibody targeting extracellular HSP90alpha to suppress endothelial-mesenchymal transition-enhanced tumor growth of pancreatic adenocarcinoma cells
Cells. 2024 Jul 04;13(13):Article number 1146.
2024-06-24
Macrophage-mediated controlled release of cysteine protease inhibitor from PLGA-PEG/hydroxyapatite microspheres for targeting cathepsin S in Alzheimer's disease
European Polymer Journal. 2024 Jun 24;214:Article number 113151.
2024-06-24
Discovery of dual MER/AXL kinase inhibitors as bifunctional small molecules for inhibiting tumor growth and enhancing tumor immune microenvironment
Journal of Medicinal Chemistry. 2024 Jun 24;Article in Press.
2024-06-01
Discovery of a long half-life AURKA inhibitor to treat MYC-amplified solid tumors as a monotherapy and in combination with everolimus
Molecular Cancer Therapeutics. 2024 Jun 01;23(6):766-779.
2024-05-28
Chlorine-containing polyacetoxybriarane diterpenoids from the octocoral Junceella fragilis
RSC Advances. 2024 May 28;14:17195-17201.
2024-05-09
Targeting cathepsin S promotes activation of OLF1-BDNF/TrkB axis to enhance cognitive function
Journal of Biomedical Science. 2024 May 09;31:Article number 46.
2024-04
Design, synthesis, and anticancer evaluation of 1-benzo[1,3]dioxol-5-yl-3-N-fused heteroaryl indoles
Molecular Diversity. 2024 Apr;28(2):595-608.
2024-04
BPR3P0128, a non-nucleoside RNA-dependent RNA polymerase inhibitor, inhibits SARS-CoV-2 variants of concern and exerts synergistic antiviral activity in combination with remdesivir
Antimicrobial Agents and Chemotherapy. 2024 Apr 3;68(4):Article number e0095623
2024-04
Reducing brain Abeta burden ameliorates high-fat diet-induced fatty liver disease in APP/PS1 mice
Biomedicine and Pharmacotherapy. 2024 Apr;173:Article number 116404.
2024-03
Probing the hair detectability of prohibited substances in sports: An in vivo-in silico-clinical approach and analytical implications compared with plasma, urine, and faeces
Archives of Toxicology. 2024 Mar;98(3):779-790.
2024-03
Multitask learning for predicting pulmonary absorption of chemicals
Food and Chemical Toxicology. 2024 Mar;185:Article number 114453.
2024-03
Immunomodulatory and anti-angiogenesis effects of excavatolide B and its derivatives in alleviating atopic dermatitis
Biomedicine and Pharmacotherapy. 2024 Mar;172:Article number 116279.
2024-02-16
Postfermented tea extract potently alleviates glucose metabolism disorders in vitro and in vivo
ACS Food Science and Technology. 2024 Feb 16;4(2):479-490.
2024-02-15
Vitamin B12 inhibits peptidylarginine deiminases and ameliorates rheumatoid arthritis in CAIA mice
Biochemical and Biophysical Research Communications. 2024 Feb 15;704:Article number 149668.
2024-01-23
Decrypting orphan GPCR drug discovery via multitask learning
Journal of Cheminformatics. 2024 Jan 23;16:Article number 10.
2024-01-22
Fipronil disturbs the antigen-specific immune responses and GABAergic gene expression in the ovalbumin-immunized BALB/c mice
BMC Veterinary Research. 2024 Jan 22;20:Article number 30.
2024-01-10
Exploring the relationship between gut microbiome composition and blood indole-3-acetic acid in hemodialysis patients
Biomedicines. 2024 Jan 10;12(1):Article number 148.
2023-12
Pulmonary delivery of remdesivir and dexamethasone encapsulated nanostructured lipid carriers for enhanced inflammatory suppression in lung
Journal of Drug Delivery Science and Technology. 2023 Dec;90:Article number 105144.
2023-11-15
Analysis of structure–activity relationship of indol-3-yl-N-phenylcarbamic amides as potent STING inhibitors
Bioorganic and Medicinal Chemistry. 2023 Nov 15;95:Article number 117502.
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