國家衛生研究院 NHRI:Item 3990099045/1986
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    題名: CTX-M-14, a plasmid-mediated CTX-M type extended-spectrum beta-lactamase isolated from Escherichia coli
    作者: Ma, L;Ishii, Y;Chang, FY;Yamaguchi, K;Ho, M;Siu, LK
    貢獻者: Division of Clinical Research
    摘要: Four Escherichia coli isolates harboring CTX-M-14, with a single Ala231-->Val substitution compared to CTX-M-9, had three different ribotypes. Cefotaxime resistance was plasmid encoded and conjugatively transferable. Three isolates had the same plasmid restriction enzyme digestion profile, suggesting clonal spread of a resistant plasmid. A high k(cat)/K-m value for cefotaxime (20.3 muM(-1) s(-1)) but low values for ceftazidime and aztreonam (<0.02 muM(-1) s(-1)) were observed in hydrolysis assays, indicating resistance to cefotaxime (MIC 64 mug/ml) but susceptibility to ceftazidime (MIC less than or equal to 2 mug/ml).
    關鍵詞: Microbiology;Pharmacology & Pharmacy
    日期: 2002-06
    關聯: Antimicrobial Agents and Chemotherapy. 2002 Jun;46(6):1985-1988.
    Link to: http://dx.doi.org/10.1128/AAC.46.6.1985-1988.2002
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0066-4804&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000175662800056
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0036090529
    顯示於類別:[蕭樑基] 期刊論文
    [何曼德(1997-2002)] 期刊論文

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