國家衛生研究院 NHRI:Item 3990099045/1986

NHRI > National Institute of Infectious Diseases and Vaccinology > Leung-Kei Siu > Periodical Articles > Item 3990099045/1986

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/1986

Title:	CTX-M-14, a plasmid-mediated CTX-M type extended-spectrum beta-lactamase isolated from Escherichia coli
Authors:	Ma, L;Ishii, Y;Chang, FY;Yamaguchi, K;Ho, M;Siu, LK
Contributors:	Division of Clinical Research
Abstract:	Four Escherichia coli isolates harboring CTX-M-14, with a single Ala231-->Val substitution compared to CTX-M-9, had three different ribotypes. Cefotaxime resistance was plasmid encoded and conjugatively transferable. Three isolates had the same plasmid restriction enzyme digestion profile, suggesting clonal spread of a resistant plasmid. A high k(cat)/K-m value for cefotaxime (20.3 muM(-1) s(-1)) but low values for ceftazidime and aztreonam (<0.02 muM(-1) s(-1)) were observed in hydrolysis assays, indicating resistance to cefotaxime (MIC 64 mug/ml) but susceptibility to ceftazidime (MIC less than or equal to 2 mug/ml).
Keywords:	Microbiology;Pharmacology & Pharmacy
Date:	2002-06
Relation:	Antimicrobial Agents and Chemotherapy. 2002 Jun;46(6):1985-1988.
Link to:	http://dx.doi.org/10.1128/AAC.46.6.1985-1988.2002
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0066-4804&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000175662800056
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0036090529
Appears in Collections:	[Leung-Kei Siu] Periodical Articles [Monto Ho(1997-2002)] Periodical Articles

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