 |
English
|
正體中文
|
简体中文
|
Items with full text/Total items : 12145/12927 (94%)
Visitors : 857777
Online Users : 811
|
|
|
Loading...
|
Please use this identifier to cite or link to this item:
http://ir.nhri.org.tw/handle/3990099045/1815
|
| Title: | Genetic variation in aldosterone synthase predicts plasma glucose levels |
| Authors: | Ranade, K;Wu, KD;Risch, N;Olivier, M;Pei, D;Hsiao, CF;Chuang, LM;Ho, LT;Jorgenson, E;Pesich, R;Chen, YDI;Dzau, V;Lin, A;Olshen, RA;Curb, D;Cox, DR;Botstein, D |
| Contributors: | Division of Biostatistics and Bioinformatics |
| Abstract: | The mineralocorticoid hormone, aldosterone, is known to play a role in sodium homeostasis. We serendipitously found, however, highly significant association between sing le-nucleotide polymorphisms in the alosterone synthase gene and plasma glucose levels in a large population of Chinese and Japanese origin, Two polymorphisms-one in the putative promoter (T-344C) and another resulting in a lysine/arginine substitution at amino acid 173, which are in complete linkage disequilibrium in this population-were associated with fasting plasma glucose levels (P = 0.000017) and those 60 (P = 0.017) and 120 (P = 0.0019) min after an oral glucose challenge. A C/T variant in intron 1, between these polymorphisms, was not associated with glucose levels. Arg-173 and -344C homozygotes were most likely to be diabetic [odds ratio 2.51; 95% confidence interval (C.I.) 1.39-3.92; P = 0.0015] and have impaired fasting glucose levels (odds ratio 3.53; 95% C.I. 2.02-5.5; P = 0.0000036). These results suggest a new role for aldosterone in glucose homeostasis. |
| Keywords: | Multidisciplinary Sciences |
| Date: | 2001-11-06 |
| Relation: | Proceedings of the National Academy of Sciences of the United States of America. 2001 Nov;98(23):13219-13224. |
| Link to: | http://dx.doi.org/10.1073/pnas.221467098 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0027-8424&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000172076800070 |
| Cited Times(Scopus): | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0035818572 |
| Appears in Collections: | [蕭金福] 期刊論文
|
Files in This Item:
| File |
Description |
Size | Format | |
|---|
| 000172076800070.pdf | | 106Kb | Adobe PDF | 428 | View/Open |
|
All items in NHRI are protected by copyright, with all rights reserved.
|
