國家衛生研究院 NHRI:Item 3990099045/1815
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    题名: Genetic variation in aldosterone synthase predicts plasma glucose levels
    作者: Ranade, K;Wu, KD;Risch, N;Olivier, M;Pei, D;Hsiao, CF;Chuang, LM;Ho, LT;Jorgenson, E;Pesich, R;Chen, YDI;Dzau, V;Lin, A;Olshen, RA;Curb, D;Cox, DR;Botstein, D
    贡献者: Division of Biostatistics and Bioinformatics
    摘要: The mineralocorticoid hormone, aldosterone, is known to play a role in sodium homeostasis. We serendipitously found, however, highly significant association between sing le-nucleotide polymorphisms in the alosterone synthase gene and plasma glucose levels in a large population of Chinese and Japanese origin, Two polymorphisms-one in the putative promoter (T-344C) and another resulting in a lysine/arginine substitution at amino acid 173, which are in complete linkage disequilibrium in this population-were associated with fasting plasma glucose levels (P = 0.000017) and those 60 (P = 0.017) and 120 (P = 0.0019) min after an oral glucose challenge. A C/T variant in intron 1, between these polymorphisms, was not associated with glucose levels. Arg-173 and -344C homozygotes were most likely to be diabetic [odds ratio 2.51; 95% confidence interval (C.I.) 1.39-3.92; P = 0.0015] and have impaired fasting glucose levels (odds ratio 3.53; 95% C.I. 2.02-5.5; P = 0.0000036). These results suggest a new role for aldosterone in glucose homeostasis.
    关键词: Multidisciplinary Sciences
    日期: 2001-11-06
    關聯: Proceedings of the National Academy of Sciences of the United States of America. 2001 Nov;98(23):13219-13224.
    Link to: http://dx.doi.org/10.1073/pnas.221467098
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0027-8424&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000172076800070
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0035818572
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