邻近类别 會議論文/會議摘要 [1/2] 类别统计 近3年内发表的文件:4(22.22%) 含全文笔数:18(100.00%) 文件下载次数统计 下载大于0次:18(100.00%) 下载大于100次:16(88.89%) 全文下载总次数:7064(95.46%) 最后更新时间: 2024-12-01 13:28 上传排行 数据加载中..... 下载排行 数据加载中..... 最近上传 DBPR116, a prodrug of BPRMU191, in ... Discovery of a mu-opioid receptor m... Development of furanopyrimidine-bas... Selective and antagonist-dependent ... Colloidal assemblies composed of po... Overcoming vincristine resistance i... Drug-like property optimization: Di... Identification of novel quinoline i... Discovery of a furanopyrimidine-bas... Design of a potent anticancer lead ...

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日期	题名	關聯
2024-10-29	DBPR116, a prodrug of BPRMU191, in combination with naltrexone as a safer opioid analgesic than morphine via peripheral administration	Journal of Medicinal Chemistry. 2024 Oct 29;Article in Press.
2024-07-17	Discovery of a mu-opioid receptor modulator that in combination with morphinan antagonists induces analgesia	Cell Chemical Biology. 2024 Jul 17;Article in Press.
2023-02-07	Development of furanopyrimidine-based orally active third-generation EGFR inhibitors for the treatment of non-small cell lung cancer	Journal of Medicinal Chemistry. 2023 Feb 7;66(4):2566-2588.
2022-11	Selective and antagonist-dependent µ-opioid receptor activation by the combination of 2-{[2-(6-chloro-3,4-dihydro-1(2H)-quinolinyl)-2-oxoethyl]sulfanyl}-5-phenyl-4,6-(1H,5H)-pyrimidinedione and naloxone/naltrexone	Bioorganic Chemistry. 2022 Nov;128:Article number 105905.
2021-07-16	Colloidal assemblies composed of polymeric micellar/emulsified systems integrate cancer therapy combining a tumor-associated antigen vaccine and chemotherapeutic regimens	Nanomaterials. 2021 Jul 16;11(7):Article number 1844.
2021-01	Overcoming vincristine resistance in cancer: Computational design and discovery of piperine-inspired P-glycoprotein inhibitors	Chemical Biology and Drug Design. 2021 Jan;97(1):51-66.
2020-08	Design of a potent anticancer lead inspired by natural products from traditional Indian medicine	Journal of Biomolecular Structure and Dynamics. 2020 Aug;38(12):3563-3577.
2020-05	Drug-like property optimization: Discovery of orally bioavailable quinazoline-based multi-targeted kinase inhibitors	Bioorganic Chemistry. 2020 May;98:Article number 103689.
2020-01	Identification of novel quinoline inhibitor for EHMT2/G9a through virtual screening	Biochimie. 2020 Jan;168:220-230.
2019-12	Lysosomal cysteine protease cathepsin S is involved in cancer cell motility by regulating store-operated Ca(2+) entry	Biochimica et Biophysica Acta. Molecular Cell Research. 2019 Dec;1866(12):Article number 118517.
2019-11-27	Discovery of a furanopyrimidine-based epidermal growth factor receptor inhibitor (DBPR112) as a clinical candidate for the treatment of non-small cell lung cancer	Journal of Medicinal Chemistry. 2019 Nov 27;62(22):10108-10123.
2019-04-01	The in vivo antinociceptive and mu-opioid receptor activating effects of the combination of N-phenyl-2′,4′-dimethyl-4,5′-bi-1,3-thiazol-2-amines and naloxone	European Journal of Medicinal Chemistry. 2019 Apr 1;167:312-323.
2018-04	4-Bromophenylhydrazinyl benzenesulfonylphenylureas as indoleamine 2,3-dioxygenase inhibitors with in vivo target inhibition and anti-tumor efficacy	Bioorganic Chemistry. 2018 Apr;77:600-607.
2017-01	Discovery, structure-activity relationship studies, and anti-nociceptive effects of N-(1,2,3,4-tetrahydro-1-isoquinolinylmethyl)benzamides as novel opioid receptor agonists	European Journal of Medicinal Chemistry. 2017 Jan;126:202-217.
2016-01	Important hydrogen bond networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) inhibitor design revealed by crystal structures of imidazoleisoindole derivatives with IDO1	Journal of Medicinal Chemistry. 2016 Jan;59 (1):282-293.
2016-01	Phenyl benzenesulfonylhydrazides exhibit selective Indoleamine 2,3-Dioxygenase inhibition with potent in vivo pharmacodynamic activity and antitumor efficacy	Journal of Medicinal Chemistry. 2016 Jan;59(1):419-430.
2015-10	Identification of substituted naphthotriazolediones as novel tryptophan 2,3-dioxygenase (TDO) inhibitors through structure-based virtual screening	Journal of Medicinal Chemistry. 2015 Oct;58 (19):7807-7819.
2014-08	Discovery and structure-activity relationships of phenyl benzenesulfonylhydrazides as novel indoleamine 2,3-dioxygenase inhibitors	Bioorganic and Medicinal Chemistry Letters. 2014 Aug;24(15):3403-3406.

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