BackgroundNon-invasive 40 Hz gamma frequency stimulation has shown improved cognition and memory recall in Alzheimer's disease (AD). PurposeThe present study investigates the effects of white light stimulation at gamma frequency on SH-SY5Y cells using Delta M + BrainCare Light without causing discomfort. MethodsSH-SY5Y cells were exposed to The Delta M + BrainCare Light for 15, 30, 45, and 60 minutes. The secretion of amyloid-beta 42 (A beta 42), p-AKT (Ser473), AKT, p-mTOR (Ser2448), mTOR, p-4E-BP1 (Thr37/46), 4E-BP1, p-tau (Thr181), and tau were analyzed. A beta 42 fibril aggregation and phagocytosis of FITC-A beta 42 in BV-2 cells were also observed. ResultsDelta M + BrainCare Light reduced tau, AKT, and p-mTOR and increased p-4E-BP1 in SH-SY5Y cells. Further, it inhibited secretion and aggregation of A beta 42, alongside increased phagocytosis in microglial cells. ConclusionThese findings underscore the potential of the Delta M + BrainCare Light in mitigating the associated proteins and pathways implicated in AD.
Date:
2024-03-04
Relation:
American Journal of Alzheimers Disease and Other Dementias. 2024 Mar 04;Article in Press.
