國家衛生研究院 NHRI:Item 3990099045/15727
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    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/15727


    题名: White light stimulation at Gamma frequency to modify the Abeta42 and tau proteins in SH-SY5Y cells
    其它题名: White light stimulation at Gamma frequency to modify the Aβ42 and tau proteins in SH-SY5Y cells
    作者: Chang, YP;Chien, CF;Huang, LC;Chuu, CP;Chang, HW;Hour, TC;Yang, YH
    贡献者: Institute of Cellular and Systems Medicine
    摘要: BackgroundNon-invasive 40 Hz gamma frequency stimulation has shown improved cognition and memory recall in Alzheimer's disease (AD). PurposeThe present study investigates the effects of white light stimulation at gamma frequency on SH-SY5Y cells using Delta M + BrainCare Light without causing discomfort. MethodsSH-SY5Y cells were exposed to The Delta M + BrainCare Light for 15, 30, 45, and 60 minutes. The secretion of amyloid-beta 42 (A beta 42), p-AKT (Ser473), AKT, p-mTOR (Ser2448), mTOR, p-4E-BP1 (Thr37/46), 4E-BP1, p-tau (Thr181), and tau were analyzed. A beta 42 fibril aggregation and phagocytosis of FITC-A beta 42 in BV-2 cells were also observed. ResultsDelta M + BrainCare Light reduced tau, AKT, and p-mTOR and increased p-4E-BP1 in SH-SY5Y cells. Further, it inhibited secretion and aggregation of A beta 42, alongside increased phagocytosis in microglial cells. ConclusionThese findings underscore the potential of the Delta M + BrainCare Light in mitigating the associated proteins and pathways implicated in AD.
    日期: 2024-03-04
    關聯: American Journal of Alzheimers Disease and Other Dementias. 2024 Mar 04;Article in Press.
    Link to: http://dx.doi.org/10.1177/15333175241236251
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1533-3175&DestApp=IC2JCR
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85186898929
    显示于类别:[褚志斌] 期刊論文

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