國家衛生研究院 NHRI:Item 3990099045/1438
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    题名: Manipulation of microglial activation as a therapeutic strategy in Alzheimer's disease
    作者: Shie, FS;Woltjer, RL
    贡献者: Division of Mental Health and Substance Abuse Research
    摘要: Alzheimer's disease (AD) is the leading cause of dementia. Although the etiology of AD remains controversial, the amyloid hypothesis suggests that amyloid (A peptides may contribute to brain dysfunction, and microglial activation has become increasingly regarded as a potential contributor to disease pathogenesis. Microglial activation is characterized by morphological changes and by production of various effectors, and activated neuroinflammation concurrent with increased oxidative stress may contribute to damage to neurons. However, recently there has been a recognition that microglia may also play a neuroprotective role through their release of neurotrophic factors and through phagocytosis of A beta. Thus, there is growing consensus that a favorable combination of diminished microglia-mediated neuroinflammation and enhanced A beta clearance may be critical in AD therapy. In this review, we will discuss the role of microglial activation in AD and how pharmacologic manipulation of microglia might bear upon the treatment of AD.
    关键词: Biochemistry & Molecular Biology;Chemistry, Medicinal;Pharmacology & Pharmacy
    日期: 2007
    關聯: Current Medicinal Chemistry. 2007;14(27):2865-2871.
    Link to: http://dx.doi.org/10.2174/092986707782359981
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0929-8673&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000253578200003
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=36749017492
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