國家衛生研究院 NHRI:Item 3990099045/1438
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/1438


    Title: Manipulation of microglial activation as a therapeutic strategy in Alzheimer's disease
    Authors: Shie, FS;Woltjer, RL
    Contributors: Division of Mental Health and Substance Abuse Research
    Abstract: Alzheimer's disease (AD) is the leading cause of dementia. Although the etiology of AD remains controversial, the amyloid hypothesis suggests that amyloid (A peptides may contribute to brain dysfunction, and microglial activation has become increasingly regarded as a potential contributor to disease pathogenesis. Microglial activation is characterized by morphological changes and by production of various effectors, and activated neuroinflammation concurrent with increased oxidative stress may contribute to damage to neurons. However, recently there has been a recognition that microglia may also play a neuroprotective role through their release of neurotrophic factors and through phagocytosis of A beta. Thus, there is growing consensus that a favorable combination of diminished microglia-mediated neuroinflammation and enhanced A beta clearance may be critical in AD therapy. In this review, we will discuss the role of microglial activation in AD and how pharmacologic manipulation of microglia might bear upon the treatment of AD.
    Keywords: Biochemistry & Molecular Biology;Chemistry, Medicinal;Pharmacology & Pharmacy
    Date: 2007
    Relation: Current Medicinal Chemistry. 2007;14(27):2865-2871.
    Link to: http://dx.doi.org/10.2174/092986707782359981
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0929-8673&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000253578200003
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=36749017492
    Appears in Collections:[Feng-Shiun Shie] Periodical Articles

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