國家衛生研究院 NHRI:Item 3990099045/14312
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12145/12927 (94%)
造訪人次 : 911274      線上人數 : 923
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/14312


    題名: Aspalathus linearis suppresses AKT signaling, c-Myc, AR and survival of enzalutamide-resistant prostate cancer cells
    作者: Chih-Pin, C;Huang, S-H;Muller, C;Wang, B-J;Chang, K-S
    貢獻者: Institute of Cellular and Systems Medicine
    摘要: Enzalutamide, a nonsteroidal antiandrogen, significantly prolonged the survival of patient with metastatic castration-resistant prostate cancer (CRPC). However, patients receiving enzalutamide frequently develop drug resistance within 1-2 years. Rooibos (Aspalathus linearis) is a shrub-like leguminous fynbos plant endemic to the Cedarberg Mountains area in South Africa. We examined if GRT may suppress the enzalutamide-resistant LNCaP C4-2 MDV3100r cells. GRT dose-dependently suppressed the proliferation, colony formation, cell cycle progression as well as induced apoptosis in MDV3100r cells. GRT suppressed the protein expression level of Akt, PI3Kα, PI3Kγ, PDK1, phospho-PDK1 S241, Skp2, cyclin D1, AR, phos-pho-AR S81, Cdk1, pro-PARP, cMyc and Bcl-2 but increased abundance of caspase 3 and cleaved-PARP. GRT reduced the abundance of AR proteins both in nucleus and cytoplasm of MDV3100r cells. Overexpression of AKT and c-Myc partially antagonized the suppressive effects of GRT Our study suggested that GRT may be useful for preventing enzalutamide resistance.
    日期: 2022-02
    關聯: Cancer Science. 2022 Feb;113(S1):1338.
    Link to: https://doi.org/10.1111/cas.15292
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1347-9032&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000778583803216
    顯示於類別:[褚志斌] 會議論文/會議摘要
    [張凱雄] 會議論文/會議摘要

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    ISI000778583803216.pdf295KbAdobe PDF147檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋