國家衛生研究院 NHRI:Item 3990099045/14312

NHRI > Institute of Cellular and Systems Medicine > Chih-Pin Chuu > Conference Papers/Meeting Abstract > Item 3990099045/14312

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/14312

Title:	Aspalathus linearis suppresses AKT signaling, c-Myc, AR and survival of enzalutamide-resistant prostate cancer cells
Authors:	Chih-Pin, C;Huang, S-H;Muller, C;Wang, B-J;Chang, K-S
Contributors:	Institute of Cellular and Systems Medicine
Abstract:	Enzalutamide, a nonsteroidal antiandrogen, significantly prolonged the survival of patient with metastatic castration-resistant prostate cancer (CRPC). However, patients receiving enzalutamide frequently develop drug resistance within 1-2 years. Rooibos (Aspalathus linearis) is a shrub-like leguminous fynbos plant endemic to the Cedarberg Mountains area in South Africa. We examined if GRT may suppress the enzalutamide-resistant LNCaP C4-2 MDV3100r cells. GRT dose-dependently suppressed the proliferation, colony formation, cell cycle progression as well as induced apoptosis in MDV3100r cells. GRT suppressed the protein expression level of Akt, PI3Kα, PI3Kγ, PDK1, phospho-PDK1 S241, Skp2, cyclin D1, AR, phos-pho-AR S81, Cdk1, pro-PARP, cMyc and Bcl-2 but increased abundance of caspase 3 and cleaved-PARP. GRT reduced the abundance of AR proteins both in nucleus and cytoplasm of MDV3100r cells. Overexpression of AKT and c-Myc partially antagonized the suppressive effects of GRT Our study suggested that GRT may be useful for preventing enzalutamide resistance.
Date:	2022-02
Relation:	Cancer Science. 2022 Feb;113(S1):1338.
Link to:	https://doi.org/10.1111/cas.15292
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1347-9032&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000778583803216
Appears in Collections:	[Chih-Pin Chuu] Conference Papers/Meeting Abstract [Kai-Hsiung Chang] Conference Papers/Meeting Abstract

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