國家衛生研究院 NHRI:Item 3990099045/14276
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    題名: Genome-wide association study of smoking behaviors in a Chinese population of Taiwan
    作者: Lin, MW;Wu, CY;Weng, PY;Wu, TY;Wu, YY;Lai, CK;Hsueh, KC;Liu, IF;Leu, HB;Chen, LS;Tsai, IYW;Liang, KY
    貢獻者: Institute of Population Health Sciences
    摘要: Introduction: Tobacco smoking is one of the major risk factors for many chronic diseases and is the leading cause of preventable death in the world. Smoking behavior is a complex, multifactorial trait with both genetic and environmental factors contributing to the various phenotypes. The aims of this study were to conduct a genome-wide association study (GWAS) on smoking behaviors and to investigate the association between genes, smoking behaviors and their impact on the cardiovascular outcomes in a Chinese population of Taiwan. Methods: We have enrolled 860 ever-smoking subjects recruited from the Healthcare Center and the Department of Family Medicine in the Taipei Veterans General Hospital, and the Department of Cardiology in the Cheng Hsin Hospital. Each participant was followed-up every six month by telephone interview with a structural questionnaire to obtain the information of their smoking status, smoking quantities, quitting attempt, and major cardiovascular events in subsequent one year. The Infinium CoreExome-24 BeadChips (Illumina, San Diego, CA) were used for the genome-wide association study. The PLINK program was used for the analysis of genome-wide association study. Results: We identified several novel genes, including RIT2, CLYBL, NFAM1, LRRC8E, FAM129B, HACD1, STK32A, CCDC88C, LINC01804, PCAT2, ASIC2, CNTNAP2, were associated with smoking cessation at 6 months (with p-value 1 × 10 -4 ). Further studies to confirm our preliminary findings are warranted. Conclusion: Our results identi fied several novel genes might be associated with smoking cessation in a Chinese population of Taiwan. Further study with larger sample is required to replicate our preliminary findings.
    日期: 2022-04-07
    關聯: European Journal of Human Genetics. 2022 Apr 7;30(Suppl 1):599.
    Link to: http://dx.doi.org/10.1038/s41431-021-01026-1
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1018-4813&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000779367702582
    顯示於類別:[梁賡義] 會議論文/會議摘要

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