國家衛生研究院 NHRI:Item 3990099045/14276

NHRI > Institute of Population Health Sciences > Kung-Yee Liang > Conference Papers/Meeting Abstract > Item 3990099045/14276

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/14276

Title:	Genome-wide association study of smoking behaviors in a Chinese population of Taiwan
Authors:	Lin, MW;Wu, CY;Weng, PY;Wu, TY;Wu, YY;Lai, CK;Hsueh, KC;Liu, IF;Leu, HB;Chen, LS;Tsai, IYW;Liang, KY
Contributors:	Institute of Population Health Sciences
Abstract:	Introduction: Tobacco smoking is one of the major risk factors for many chronic diseases and is the leading cause of preventable death in the world. Smoking behavior is a complex, multifactorial trait with both genetic and environmental factors contributing to the various phenotypes. The aims of this study were to conduct a genome-wide association study (GWAS) on smoking behaviors and to investigate the association between genes, smoking behaviors and their impact on the cardiovascular outcomes in a Chinese population of Taiwan. Methods: We have enrolled 860 ever-smoking subjects recruited from the Healthcare Center and the Department of Family Medicine in the Taipei Veterans General Hospital, and the Department of Cardiology in the Cheng Hsin Hospital. Each participant was followed-up every six month by telephone interview with a structural questionnaire to obtain the information of their smoking status, smoking quantities, quitting attempt, and major cardiovascular events in subsequent one year. The Inﬁnium CoreExome-24 BeadChips (Illumina, San Diego, CA) were used for the genome-wide association study. The PLINK program was used for the analysis of genome-wide association study. Results: We identiﬁed several novel genes, including RIT2, CLYBL, NFAM1, LRRC8E, FAM129B, HACD1, STK32A, CCDC88C, LINC01804, PCAT2, ASIC2, CNTNAP2, were associated with smoking cessation at 6 months (with p-value 1 × 10 -4 ). Further studies to conﬁrm our preliminary ﬁndings are warranted. Conclusion: Our results identi ﬁed several novel genes might be associated with smoking cessation in a Chinese population of Taiwan. Further study with larger sample is required to replicate our preliminary ﬁndings.
Date:	2022-04-07
Relation:	European Journal of Human Genetics. 2022 Apr 7;30(Suppl 1):599.
Link to:	http://dx.doi.org/10.1038/s41431-021-01026-1
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1018-4813&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000779367702582
Appears in Collections:	[Kung-Yee Liang] Conference Papers/Meeting Abstract

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