國家衛生研究院 NHRI:Item 3990099045/13531
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    題名: In vivo assessment of hypoxia levels in pancreatic tumors using a dual-modality ultrasound/photoacoustic imaging system
    作者: Wang, Y;Jhang, DF;Tsai, CH;Chiang, NJ;Tsao, CH;Chuang, CC;Chen, LT;Wayne Chang, WS;Liao, LD
    貢獻者: Institute of Biomedical Engineering and Nanomedicine;National Institute of Cancer Research
    摘要: Noninvasive anatomical and functional imaging has become an essential tool to evaluate tissue oxygen saturation dynamics in preclinical or clinical studies of hypoxia. Our dual-wavelength technique for photoacoustic (PA) imaging based on the differential absorbance spectrum of oxyhe-moglobin (oxy-Hb) and deoxyhemoglobin (deoxy-Hb) can quantify tissue oxygen saturation using the intrinsic contrast property. PA imaging of tissue oxygen saturation can be used to monitor tumor-related hypoxia, which is a particularly relevant functional parameter of the tumor microenvironment that has a strong influence on tumor aggressiveness. The simultaneous acquisition of anatomical and functional information using dual-modality ultrasound (US) and PA imaging technology enhances the preclinical applicability of the method. Here, the developed dual-modality US/PA system was used to measure relative tissue oxygenation using the dual-wavelength technique. Tissue oxygen saturation was quantified in a pancreatic tumor mouse model. The differences in tissue oxygenation were detected by comparing pancreatic samples from normal and tumor-bearing mice at various time points after implantation. The use of an in vivo pancreatic tumor model revealed changes in hypoxia at various stages of tumor growth. The US/PA imaging data positively correlated with the results of immunohistochemical staining for hypoxia. Thus, our dual-modality US/PA imaging system can be used to reliably assess and monitor hypoxia in pancreatic tumor mouse models. These findings enable the use of a combination of US and PA imaging to acquire anatomical and functional information on tumor growth and to evaluate treatment responses in longitudinal preclinical studies.
    日期: 2021-06-07
    關聯: Micromachines. 2021 Jun 7;12(6):Article number 668.
    Link to: http://dx.doi.org/10.3390/mi12060668
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2072-666X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000666952500001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85108351956
    顯示於類別:[廖倫德] 期刊論文
    [張文祥] 期刊論文
    [陳立宗] 期刊論文
    [姜乃榕] 期刊論文

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