國家衛生研究院 NHRI:Item 3990099045/12989
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    題名: Does Nicastrin inadequacy cause melanocytotoxicity in human skin as in the fish counterpart?
    作者: Hsu, CH;Jiang, YJ
    貢獻者: Institute of Molecular and Genomic Medicine
    摘要: We read with interest the letter to the editor by Hermasch et al. in this journal (Hermasch et al., 2020). The authors comment on our recent findings on a zebrafish insertional nicastrin mutant (Hsu et al., 2020). We showed that zebrafish nicastrin deficiency leads to melanosome defects, Tyrosinase-dependent mitochondrial swelling, and melanophore cell death. Based on several clinical observations and animal model studies, we proposed that this animal model may be used for investigating depigmentaion-related skin diseases and for screening potential drugs (Hsu et al., 2020). Nevertheless, Hermasch et al. raise some questions and concerns, to which we reply hereafter.
    日期: 2021-05
    關聯: Journal of Investigative Dermatology. 2021 May;141(5):1334-1338.
    Link to: http://dx.doi.org/10.1016/j.jid.2020.09.016
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0022-202X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000641962000012
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85097059462
    顯示於類別:[江運金] 期刊論文

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