國家衛生研究院 NHRI:Item 3990099045/12989
English  |  正體中文  |  简体中文  |  Items with full text/Total items : 12145/12927 (94%)
Visitors : 853326      Online Users : 818
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
    •  Adv. Search
    Home ‧ Login ‧ Upload ‧ Help ‧ About ‧ Administer Goto mobile version


    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/12989


    Title: Does Nicastrin inadequacy cause melanocytotoxicity in human skin as in the fish counterpart?
    Authors: Hsu, CH;Jiang, YJ
    Contributors: Institute of Molecular and Genomic Medicine
    Abstract: We read with interest the letter to the editor by Hermasch et al. in this journal (Hermasch et al., 2020). The authors comment on our recent findings on a zebrafish insertional nicastrin mutant (Hsu et al., 2020). We showed that zebrafish nicastrin deficiency leads to melanosome defects, Tyrosinase-dependent mitochondrial swelling, and melanophore cell death. Based on several clinical observations and animal model studies, we proposed that this animal model may be used for investigating depigmentaion-related skin diseases and for screening potential drugs (Hsu et al., 2020). Nevertheless, Hermasch et al. raise some questions and concerns, to which we reply hereafter.
    Date: 2021-05
    Relation: Journal of Investigative Dermatology. 2021 May;141(5):1334-1338.
    Link to: http://dx.doi.org/10.1016/j.jid.2020.09.016
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0022-202X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000641962000012
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85097059462
    Appears in Collections:[Yun-Jin Jiang] Periodical Articles

    Files in This Item:

    File Description SizeFormat
    PUB33058861.pdf1519KbAdobe PDF233View/Open


    All items in NHRI are protected by copyright, with all rights reserved.

    Related Items in TAIR

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback