國家衛生研究院 NHRI:Item 3990099045/12651

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Title:	Effect of interleukin-1beta and glutathione S-transferase genotypes on the development of gastric mucosa-associated lymphoid tissue lymphoma
Other Titles:	Effect of interleukin-1β and glutathione S-transferase genotypes on the development of gastric mucosa-associated lymphoid tissue lymphoma
Authors:	Wu, MS;Shun, CT;Huang, SP;Cheng, AL;Chen, LT;Lin, JT
Contributors:	National Institute of Cancer Research
Abstract:	e tested whether polymorphic variations in glutathione S-transferase genes (GSTM1, GSTT1, GSTP1) and interleukin-1 (IL-1beta and IL-1RN) genes confer susceptibility to mucosa-associated lymphoid tissue lymphomas (MALT) in a Chinese population. The rates of GSTM1, GSTP1, IL-1beta and IL-1RN genotypes did not differ between patients and controls. However, GSTT1 null genotypes were significantly more common in patients with MALT lymphomas (43/75 vs. 138/321, p=0.029; OR=1.8, 95% CI: 1.1-3.0) than in controls. Our results suggest that a glutathione S-transferase defect plays a role in MALT lymphoma.
Date:	2004-08
Relation:	Haematologica. 2004 Aug;89(8):1015-1017.
Link to:	http://www.haematologica.org/content/89/8/1015.abstract
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0390-6078&DestApp=IC2JCR
Appears in Collections:	[Li-Tzong Chen] Conference Papers/Meeting Abstract

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