國家衛生研究院 NHRI:Item 3990099045/1259
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12189/12972 (94%)
造訪人次 : 955920      線上人數 : 856
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/1259


    題名: Structural basis for the structure-activity relationships of peroxisome proliferator-activated receptor agonists
    作者: Mahindroo, N;Peng, YH;Lin, CH;Tan, UK;Prakash, E;Lien, TW;Lu, IL;Lee, HJ;Hsu, JTA;Chen, X;Liao, CC;Lyu, PC;Chao, YS;Wu, SY;Hsieh, HP
    貢獻者: Division of Biotechnology and Pharmaceutical Research
    摘要: Type 2 diabetes has rapidly reached an epidemic proportion becoming a major threat to global public health. PPAR agonists have emerged as a leading class of oral antidiabetic drugs. We report a structure biology analysis of novel indole-based PPAR agonists to explain the structure-activity relationships and present a critical analysis of reasons for change in selectivity with change in the orientation of the same scaffolds. The results would be helpful in designing novel PPAR agonists.
    關鍵詞: Chemistry, Medicinal
    日期: 2006-10-19
    關聯: Journal of Medicinal Chemistry. 2006 Oct;49(21):6421-6424.
    Link to: http://dx.doi.org/10.1021/jm060663c
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0022-2623&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000241192400034
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33750123321
    顯示於類別:[謝興邦] 期刊論文
    [伍素瑩] 期刊論文
    [徐祖安] 期刊論文
    [趙宇生(2002-2013)] 期刊論文
    [陳新(2002-2015)] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    000241192400034.pdf152KbAdobe PDF706檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋