國家衛生研究院 NHRI:Item 3990099045/1259
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    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/1259


    题名: Structural basis for the structure-activity relationships of peroxisome proliferator-activated receptor agonists
    作者: Mahindroo, N;Peng, YH;Lin, CH;Tan, UK;Prakash, E;Lien, TW;Lu, IL;Lee, HJ;Hsu, JTA;Chen, X;Liao, CC;Lyu, PC;Chao, YS;Wu, SY;Hsieh, HP
    贡献者: Division of Biotechnology and Pharmaceutical Research
    摘要: Type 2 diabetes has rapidly reached an epidemic proportion becoming a major threat to global public health. PPAR agonists have emerged as a leading class of oral antidiabetic drugs. We report a structure biology analysis of novel indole-based PPAR agonists to explain the structure-activity relationships and present a critical analysis of reasons for change in selectivity with change in the orientation of the same scaffolds. The results would be helpful in designing novel PPAR agonists.
    关键词: Chemistry, Medicinal
    日期: 2006-10-19
    關聯: Journal of Medicinal Chemistry. 2006 Oct;49(21):6421-6424.
    Link to: http://dx.doi.org/10.1021/jm060663c
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0022-2623&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000241192400034
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33750123321
    显示于类别:[謝興邦] 期刊論文
    [伍素瑩] 期刊論文
    [徐祖安] 期刊論文
    [趙宇生(2002-2013)] 期刊論文
    [陳新(2002-2015)] 期刊論文

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