國家衛生研究院 NHRI:Item 3990099045/11710
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    题名: The relationship between air pollution and lung cancer in non-smokers in Taiwan
    作者: Tseng, CH;Tsuang, BJ;Chiang, CJ;Ku, KC;Tseng, JS;Yang, TY;Hsu, KH;Chen, KC;Yu, SL;Lee, WC;Liu, TW;Chan, CC;Chang, GC
    贡献者: National Institute of Cancer Research
    摘要: INTRODUCTION: For never-smokers (smoked <100 lifetime cigarettes), lung cancer (LC) has emerged as an important issue. We aimed to investigate the effects of prevalence changes in tobacco smoking and particulate matter (PM) 2.5 (PM2.5) levels on LC in Taiwan, in relation to contrasting PM2.5 levels, between northern Taiwan (NT) and southern Taiwan (ST). METHODS: We reviewed 371,084 patients with LC to assess smoking prevalence and correlations between the incidence of adenocarcinoma lung cancer (AdLC) and non-AdLC. Two subsets were selected to assess different AdLC stage trends and the effect of PM2.5 on survival of patients with AdLC. RESULTS: From 1995 to 2015, the proportion of male adult ever smokers decreased from 59.4% to 29.9% while the female smoking rate remained low (3.2%-5.3%). AdLC incidence in males and females increased from 9.06 to 23.25 and 7.05 to 24.22 per 100,000 population, respectively. Since 1993, atmospheric visibility in NT improved (from 7.6 to 11.5 km), but deteriorated in ST (from 16.3 to 4.2 km). In 2007, the annual percent change in AdLC stages IB to IV was 0.3% (95% confidence interval [CI], 1.9%-2.6%) in NT, and 4.6% (3.3%-5.8%) in ST; 53% patients with LC had never smoked. Five-year survival rates for never-smokers, those with EGFR wild-type genes, and female patients with AdLC were 12.6% in NT and 4.5% in ST (hazard ratio 0.79, 95% CI; 0.70-0.90). CONCLUSIONS: In Taiwan, >50% patients with LC had never smoked. PM2.5 level changes can affect AdLC incidence and patient survival.
    日期: 2019-05
    關聯: Journal of Thoracic Oncology. 2019 May;14(5):784-792.
    Link to: http://dx.doi.org/10.1016/j.jtho.2018.12.033
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1556-0864&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000465298700018
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85061898090
    显示于类别:[劉滄梧] 期刊論文

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