國家衛生研究院 NHRI:Item 3990099045/11657
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    题名: The association between carotid flow and cognitive function in the community elderly population
    作者: Chuang, SY;Cheng, HM;Yip, BS;Chen, CH;Pan, WH
    贡献者: Institute of Population Health Sciences
    摘要: Objective: Carotid hemodynamics, such as intima-media thickness and carotid fl ow velocity were associated with stroke events. However, the association between carotid hemodynamics and cognitive function remains not fully clear. We aimed to investigate the relationship between carotid fl ow velocity and cognitive function. Design and method: A total of 744 elderly (more than 60 years) subjects completed the baseline and followed ultrasound examinations and those were evaluat-ed cognitive function. Cognitive function was evaluated by MMSE and cognitive function impairment was defi ned by the MMSE less than 26. The peak-systolic velocity, end-diastolic velocity were measured in the common carotid arteries. Logistic regression was used to evaluate the association between carotid fl ow velocities, carotid diameters and cognitive function. Results: A total of 744 elderly subjects completed all examinations during the followed period. The prevalence Cognitive function impairment (MMSE less than 26) was 13.3% (n = 99). The peak systolic velocity (PSV) and diastolic end velocity (EDV) were lower in those with cognitive function impairment (60.5 vs. 65.5 cm/sec, p-value < 0.001 for PSV and 19.7 vs. 22.1 cm/sec, p-value < 0.001 for EDV), and only peak-systolic velocity remains signifi cant in the multivariable models. Moreover, those with lower carotid fl ow velocities (the lowest 10th of peak systolic velocity) had 9.69 fold risk (95% confi dence intervals: 2.75–34.21) of cognitive function impairment, compared to those with the highest 10th of peak systolic velocity. The signifi cant association remains in the multivariable model by adjusting for age, gender, education, brachial systolic BP, fasting glucose, and low density lipoprotein cholesterol. Conclusions: Low carotid fl ow velocity, especially peak-systolic velocity was associated with cognitive function impairment. Lower carotid fl ow may involve the pathogen of cognitive function impairment in the general elderly population.
    日期: 2018-06
    關聯: Journal of Hypertension. 2018 Jun;36:E90.
    Link to: http://dx.doi.org/10.1097/01.hjh.0000539227.11146.2f
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0263-6352&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000455593900275
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