國家衛生研究院 NHRI:Item 3990099045/11657

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Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/11657

Title:	The association between carotid flow and cognitive function in the community elderly population
Authors:	Chuang, SY;Cheng, HM;Yip, BS;Chen, CH;Pan, WH
Contributors:	Institute of Population Health Sciences
Abstract:	Objective: Carotid hemodynamics, such as intima-media thickness and carotid ﬂ ow velocity were associated with stroke events. However, the association between carotid hemodynamics and cognitive function remains not fully clear. We aimed to investigate the relationship between carotid ﬂ ow velocity and cognitive function. Design and method: A total of 744 elderly (more than 60 years) subjects completed the baseline and followed ultrasound examinations and those were evaluat-ed cognitive function. Cognitive function was evaluated by MMSE and cognitive function impairment was deﬁ ned by the MMSE less than 26. The peak-systolic velocity, end-diastolic velocity were measured in the common carotid arteries. Logistic regression was used to evaluate the association between carotid ﬂ ow velocities, carotid diameters and cognitive function. Results: A total of 744 elderly subjects completed all examinations during the followed period. The prevalence Cognitive function impairment (MMSE less than 26) was 13.3% (n = 99). The peak systolic velocity (PSV) and diastolic end velocity (EDV) were lower in those with cognitive function impairment (60.5 vs. 65.5 cm/sec, p-value < 0.001 for PSV and 19.7 vs. 22.1 cm/sec, p-value < 0.001 for EDV), and only peak-systolic velocity remains signiﬁ cant in the multivariable models. Moreover, those with lower carotid ﬂ ow velocities (the lowest 10th of peak systolic velocity) had 9.69 fold risk (95% conﬁ dence intervals: 2.75–34.21) of cognitive function impairment, compared to those with the highest 10th of peak systolic velocity. The signiﬁ cant association remains in the multivariable model by adjusting for age, gender, education, brachial systolic BP, fasting glucose, and low density lipoprotein cholesterol. Conclusions: Low carotid ﬂ ow velocity, especially peak-systolic velocity was associated with cognitive function impairment. Lower carotid ﬂ ow may involve the pathogen of cognitive function impairment in the general elderly population.
Date:	2018-06
Relation:	Journal of Hypertension. 2018 Jun;36:E90.
Link to:	http://dx.doi.org/10.1097/01.hjh.0000539227.11146.2f
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0263-6352&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000455593900275
Appears in Collections:	[Shao-Yuan Chuang] Conference Papers/Meeting Abstract

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