國家衛生研究院 NHRI:Item 3990099045/1136

NHRI > Institute of Biotechnology and Pharmaceutical Research > Kak-Shan Shia > Periodical Articles > Item 3990099045/1136

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/1136

Title:	Lithium naphthalenide induced reductive selenenylation of alpha-cyano ketones: A regiocontrolled process for alpha-phenylseleno ketones and one-pot conversion into enone system
Authors:	Zhu, JL;Ko, YC;Kuo, CW;Shia, KS
Contributors:	Division of Biotechnology and Pharmaceutical Research
Abstract:	An efficient procedure for the regiocontrolled synthesis of a-phenylseleno ketones has been developed, making use of the lithium naphthalenide induced reductive selenenylation of the alpha-cyano ketone system as a key operation. Moreover, seleno ketones thus generated in situ, upon subsequent treatment with hydrogen peroxide and acetic acid, could be further converted into the corresponding enones with a high degree of regioselectivity, presumably due to the lithium salt mediated selenoxide syn-elimination process.
Keywords:	Chemistry, Organic
Date:	2007-05-16
Relation:	Synlett. 2007 May(8):1274-1278.
Link to:	http://dx.doi.org/10.1055/s-2007-977448
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0936-5214&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000247217700021
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=34249784824
Appears in Collections:	[Kak-Shan Shia] Periodical Articles

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