國家衛生研究院 NHRI:Item 3990099045/11133

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Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/11133

Title:	Increasing trends of anaphylaxis-related events: An analysis of anaphylaxis nationwide data in Taiwan, 2001-2013
Authors:	Yao, TC;Huang, YW;Wu, HT;Tsai, YT;Wang, JY;Tsai, HJ
Contributors:	Institute of Population Health Sciences
Abstract:	RATIONALE: Anaphylaxis is a severe, potentially fatal, and systemic allergic reaction. Previous studies document increasing trends in the incidence and rates of anaphylaxis-related events in Western countries; however, few studies have been reported in Asian countries. We aimed to determine trends in incident rates of anaphylaxis-related events in Taiwan from 2001 through 2013. METHODS: We utilized medical claims data from the National Health Insurance Research Database in Taiwan. We identiﬁed anaphylaxis-related events and calculated incident rates, accordingly. Regression-based analyses were applied to examine trends and incident rates across study years. RESULTS: A total of 2,496 patients with ﬁrst-time anaphylaxis were identiﬁed. The mean (standard deviation) age was 45.11 (20.64) years, and 56% of patients were male. The overall incident rate of anaphylaxis-related outpatient events was 6.94 (95% CI 5 6.77-7.22) per 100,000 person-years. When stratifying by age, signiﬁcant increasing incident rates were observed among subjects aged < 18, 19-39, and 40-59 years (all p _ trend < 0.01), but not among subjects aged > 60 years. Among 2,496 patients, 1,696 (68.0%) patients were identiﬁed only from outpatient or emergency department (ED) visits, 495 (19.8%) patients were hospitalized, and 305 (12.2%) hospitalized patients were admitted to intensive care units. Furthermore, time trend of anaphylaxis-related outpatient or ED visits has increased over time ( p _trend 5 0.01), but time trend of anaphylaxisrelated hospitalization has decreased over time ( p _trend < 0.01). CONCLUSIONS: In this study, we observed the increasing incident rate of anaphylaxis-related events over time. The increasing incident rates were associated with different age groups, but not among subjects aged > 60 years.
Date:	2018-02
Relation:	Journal of Allergy and Clinical Immunology. 2018 Feb;141(2, Suppl.):AB153.
Link to:	https://doi.org/10.1016/j.jaci.2017.12.489
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0091-6749&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000429306700484
Appears in Collections:	[Hui-Ju Tsai] Conference Papers/Meeting Abstract

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