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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/11012


    Title: Synergic effect of curcumin and its structural analogue (Monoacetylcurcumin) on anti-influenza virus infection
    Authors: Richart, SM;Li, YL;Mizushina, Y;Chang, YY;Chung, TY;Chen, GH;Tzen, JTC;Shia, KS;Hsu, WL
    Contributors: Institute of Biotechnology and Pharmaceutical Research
    Abstract: Curcumin (Cur), a polyphenolic compound extracted from spice and common food colourant turmeric, contains versatile bio-activities. Monoacetylcurcumin (MAC), a structural analogue of Cur, differs from Cur by acetyl modification, but retains enone groups. Comparative analysis revealed MAC effectively inhibited influenza virus infection (IAV) to a similar extent as, if not superior to, curcumin. Both compounds mildly reduced viral NA activity. Surprisingly, unlike Cur, the MAC inhibition of IAV did not occur through the blocking of HA activity. However, MAC strongly dampened Akt phosphorylation, the prerequisite signalling for efficient IAV propagation. A much stronger inhibition effect on IAV infection was observed when MAC treatment was in combination with Cur. Collectively, MAC demonstrated clear antiviral activity, and likely inhibited IAV via multiple mechanisms that were not identical to Cur. Importantly, Cur and MAC in combination synergistically inhibited IAV infection.
    Date: 2018-07
    Relation: Journal of Food and Drug Analysis. 2018 Jul;26(3):1015-1023.
    Link to: http://dx.doi.org/10.1016/j.jfda.2017.12.006
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1021-9498&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000437809200008
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85041344063
    Appears in Collections:[夏克山] 期刊論文

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