國家衛生研究院 NHRI:Item 3990099045/11012
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    题名: Synergic effect of curcumin and its structural analogue (Monoacetylcurcumin) on anti-influenza virus infection
    作者: Richart, SM;Li, YL;Mizushina, Y;Chang, YY;Chung, TY;Chen, GH;Tzen, JTC;Shia, KS;Hsu, WL
    贡献者: Institute of Biotechnology and Pharmaceutical Research
    摘要: Curcumin (Cur), a polyphenolic compound extracted from spice and common food colourant turmeric, contains versatile bio-activities. Monoacetylcurcumin (MAC), a structural analogue of Cur, differs from Cur by acetyl modification, but retains enone groups. Comparative analysis revealed MAC effectively inhibited influenza virus infection (IAV) to a similar extent as, if not superior to, curcumin. Both compounds mildly reduced viral NA activity. Surprisingly, unlike Cur, the MAC inhibition of IAV did not occur through the blocking of HA activity. However, MAC strongly dampened Akt phosphorylation, the prerequisite signalling for efficient IAV propagation. A much stronger inhibition effect on IAV infection was observed when MAC treatment was in combination with Cur. Collectively, MAC demonstrated clear antiviral activity, and likely inhibited IAV via multiple mechanisms that were not identical to Cur. Importantly, Cur and MAC in combination synergistically inhibited IAV infection.
    日期: 2018-07
    關聯: Journal of Food and Drug Analysis. 2018 Jul;26(3):1015-1023.
    Link to: http://dx.doi.org/10.1016/j.jfda.2017.12.006
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1021-9498&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000437809200008
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85041344063
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