國家衛生研究院 NHRI:Item 3990099045/11002
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    题名: Flexible modulation of CO-Release using various nuclearity of metal carbonyl clusters on graphene oxide for stroke remediation
    作者: Tan, MJ;Pan, HC;Tan, HR;Chai, JW;Lim, QF;Wong, TI;Zhou, X;Hong, ZY;Liao, LD;Kong, KV
    贡献者: Institute of Biomedical Engineering and Nanomedicine
    摘要: Utilizing the size-dependent adsorption properties of ruthenium carbonyl clusters (Ru-carbon monoxide (CO)) onto graphene oxide (GO), a facile CO-release platform for in situ vasodilation as a treatment for stroke-related vascular diseases is developed. The rate and amount of formation of the CO-release-active Ru(II) (CO)2 species can be modulated by a simple mixing procedure at room temperature. The subsequent thermally induced oxidation of Ru(II) (CO)2 to RuO2 on the GO surface results in the release of CO. Further modulation of thermal and CO-release properties can be achieved via a hybridization of medium- and high-nuclearity of Ru-CO clusters that produces a RuO2 /Ru(II) (CO)2 /(6) Ru-CO-GO composite, where (6) Ru-CO-GO provides a photothermally activated reservoir of Ru(II) (CO)2 species and the combined infrared absorption properties of GO and RuO2 provides photothermal response for in situ CO-release. The RuO2 /Ru(II) (CO)2 /(6) Ru-CO-GO composite does not produce any cytotoxicity and the efficacy of the composite is further demonstrated in a cortical photothrombotic ischemia rat model.
    日期: 2018-03
    關聯: Advanced Healthcare Materials. 2018 Mar;7(5):Article number 1701113.
    Link to: http://dx.doi.org/10.1002/adhm.201701113
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2192-2640&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000426758500022
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85040678880
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