國家衛生研究院 NHRI:Item 3990099045/10731
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12145/12927 (94%)
造訪人次 : 912315      線上人數 : 1167
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/10731


    題名: Establishment of salt-induced chronic kidney disease in stroke-prone spontaneously hypertensive rats (SHRSP) and its therapeutic effect of kefir-derived peptides oral administration
    作者: Chen, YH;Chen, HL;Chen, CM
    貢獻者: NHRI Graduate Student Program
    摘要: The consequence of chronic high blood pressure is increasingly prevalence of chronic kidney disease (CKD) and cardiovascular organ injury, prevalence the high costs and poor outcomes of treatment are a significant health issue at clinical. In this study, hypothesis the Kefir-fermented product derived from milk protein (as a nature source) with the protection of the kidney function in management of salt-induced chronic kidney disease. Therefore, we used the salt-induced kidney disease in stroke-prone spontaneously hypertensive rats (SHRSP) as an animal model. SHRSP rats at 50–60 weeks of age were orally administered kefir-derived peptides (KDP) for four weeks. The results of KDP have good performance of anti- hypertension effect, further studies of immunohistochemical staining and western blotting showed that salt-induced kidney failure significantly increased the protein levels of CD68, MCP-1, α-SMA and ET-1 under 1% NaCl drinking water induction. However, treatment with KDP significantly decreased macrophage infiltration marker CD68, MCP-1, α-SMA and ET-1 levels compared to those in mock group of salt-treated SHRSP rats (P<0.05). Moreover, the results demonstrated that KDP improved salt-induced impaired kidney function. The examination of kidney histopathology further showed that KDP administration significantly decreased salt-induced glomerulosclerosis, tubular damage, collagen deposition, interlobular arterial thickness (P<0.05). These conclusion suggested that KDP exerted potent protection against salt-induced chronic kidney disease and antihypertension in SHRSP rats. Therefore, kefir-derived peptides may represent a novel kidney protective agent in clinical use.
    日期: 2017-04
    關聯: The FASEB Journal. 2017 Apr;31(1, Suppl.):Meeting Abstract 855.12.
    Link to: http://www.fasebj.org/content/31/1_Supplement/855.12.abstract?sid=fc5f961c-1ac3-47c5-a5d9-b5a255a5f716
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0892-6638&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000405986505297
    顯示於類別:[其他] 會議論文/會議摘要

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    ISI000405986505297.pdf37KbAdobe PDF310檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋